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Association of hemostatic variables with prevalent cardiovascular disease and asymptomatic carotid artery atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.

TitleAssociation of hemostatic variables with prevalent cardiovascular disease and asymptomatic carotid artery atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.
Publication TypeJournal Article
Year of Publication1993
AuthorsFolsom AR, Wu KK, Shahar E, Davis CE
JournalArterioscler Thromb
Volume13
Issue12
Pagination1829-36
Date Published1993 Dec
ISSN1049-8834
KeywordsArteriosclerosis, Cardiovascular Diseases, Carotid Artery Diseases, Continental Population Groups, Factor VII, Factor VIII, Female, Fibrinogen, Hemostasis, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Smoking, Ultrasonography, von Willebrand Factor
Abstract

The relation of hemostatic factor levels to the occurrence of cardiovascular disease is incompletely established. The Atherosclerosis Risk in Communities Study measured fibrinogen, factor VII, factor VIII, von Willebrand factor, antithrombin III, protein C, activated partial thromboplastin time, and other cardiovascular risk factors in nearly 15,000 men and women aged 45 to 64. This analysis assessed the relations of these hemostatic factors with prevalent cardiovascular disease and asymptomatic carotid artery intimal-medial thickness measured by B-mode ultrasound. Compared with participants without cardiovascular disease, those with cardiovascular disease had higher levels of fibrinogen, factor VIII, and von Willebrand factor in both sexes. The other hemostatic factors were less consistently associated with prevalent cardiovascular disease. Only fibrinogen was associated with carotid intimal-medial thickness. Adjusted for age, race, and field center, the odds ratio for carotid wall thickness in the 90th percentile or greater, compared with

DOI10.1161/01.atv.13.12.1829
Alternate JournalArterioscler Thromb
PubMed ID8241104
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-NC-55018 / / PHS HHS / United States