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Antigens of tissue plasminogen activator and plasminogen activator inhibitor 1: correlates in nonsmoking Japanese and Caucasian men and women.

TitleAntigens of tissue plasminogen activator and plasminogen activator inhibitor 1: correlates in nonsmoking Japanese and Caucasian men and women.
Publication TypeJournal Article
Year of Publication1993
AuthorsIso H, Folsom AR, Koike KA, Sato S, Wu KK, Shimamoto T, Iida M, Komachi Y
JournalThromb Haemost
Volume70
Issue3
Pagination475-80
Date Published1993 Sep 01
ISSN0340-6245
KeywordsAged, Antigens, Asian Continental Ancestry Group, Coronary Disease, European Continental Ancestry Group, Female, Humans, Japan, Male, Middle Aged, Plasminogen Activator Inhibitor 1, Risk Factors, Sex Characteristics, Tissue Plasminogen Activator
Abstract

We reported in a 1987 preliminary study that tissue plasminogen activator antigen was significantly higher in American Caucasian men than in Japanese men. To further examine possible differences in fibrinolytic activity between the two races, an expanded study was conducted in a total of 300 nonsmoking men and women aged 47-69 years in two population-based samples: rural Japanese living in Akita and Caucasians living in Minneapolis-St. Paul, MN. Antigens of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were measured. Mean t-PA antigen was 2.3 ng/ml higher in Caucasian men than in Japanese men (P

Alternate JournalThromb Haemost
PubMed ID8259552
Grant ListN01-HC-55019 / HC / NHLBI NIH HHS / United States