|Title||Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators.|
|Publication Type||Journal Article|
|Year of Publication||1994|
|Authors||Folsom AR, Eckfeldt JH, Weitzman S, Ma J, Chambless LE, Barnes RW, Cram KB, Hutchinson RG|
|Date Published||1994 Jan|
|Keywords||African Continental Ancestry Group, Aging, Blood Glucose, Body Constitution, Carotid Arteries, Coronary Artery Disease, Diabetes Mellitus, European Continental Ancestry Group, Fasting, Female, Humans, Insulin, Male, Middle Aged, Physical Exertion, Reference Values, Regression Analysis, Sex Characteristics|
BACKGROUND AND PURPOSE: We tested the hypothesis that body mass, waist-to-hip circumference ratio, physical inactivity, diabetes, hyperglycemia, and fasting insulin are each positively associated with asymptomatic carotid artery wall thickness.
METHODS: Average intimal-medial carotid wall thickness (an indicator of atherosclerosis) was measured noninvasively by B-mode ultrasonography in cross-sectional samples of 45- to 64-year-old adults, both blacks and whites, free of symptomatic cardiovascular disease, in four US communities.
RESULTS: Sample mean carotid wall thickness was approximately 0.7 mm in women (n = 7956) and 0.8 mm in men (n = 6474). Body mass, waist-to-hip ratio, work physical activity, diabetes, and fasting insulin were associated (P
CONCLUSIONS: Abdominal adiposity, physical inactivity, and abnormal glucose metabolism are associated positively with carotid intimal-medial wall thickness, suggesting these factors contribute to atherogenesis.
|Grant List||N01-HC-55015 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States