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Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators.

TitleRelation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators.
Publication TypeJournal Article
Year of Publication1994
AuthorsFolsom AR, Eckfeldt JH, Weitzman S, Ma J, Chambless LE, Barnes RW, Cram KB, Hutchinson RG
JournalStroke
Volume25
Issue1
Pagination66-73
Date Published1994 Jan
ISSN0039-2499
KeywordsAfrican Continental Ancestry Group, Aging, Blood Glucose, Body Constitution, Carotid Arteries, Coronary Artery Disease, Diabetes Mellitus, European Continental Ancestry Group, Fasting, Female, Humans, Insulin, Male, Middle Aged, Physical Exertion, Reference Values, Regression Analysis, Sex Characteristics
Abstract

BACKGROUND AND PURPOSE: We tested the hypothesis that body mass, waist-to-hip circumference ratio, physical inactivity, diabetes, hyperglycemia, and fasting insulin are each positively associated with asymptomatic carotid artery wall thickness.

METHODS: Average intimal-medial carotid wall thickness (an indicator of atherosclerosis) was measured noninvasively by B-mode ultrasonography in cross-sectional samples of 45- to 64-year-old adults, both blacks and whites, free of symptomatic cardiovascular disease, in four US communities.

RESULTS: Sample mean carotid wall thickness was approximately 0.7 mm in women (n = 7956) and 0.8 mm in men (n = 6474). Body mass, waist-to-hip ratio, work physical activity, diabetes, and fasting insulin were associated (P

CONCLUSIONS: Abdominal adiposity, physical inactivity, and abnormal glucose metabolism are associated positively with carotid intimal-medial wall thickness, suggesting these factors contribute to atherogenesis.

DOI10.1161/01.str.25.1.66
Alternate JournalStroke
PubMed ID8266385
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States