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Lipoprotein[a] as a risk factor for preclinical atherosclerosis.

TitleLipoprotein[a] as a risk factor for preclinical atherosclerosis.
Publication TypeJournal Article
Year of Publication1993
AuthorsSchreiner PJ, Morrisett JD, Sharrett AR, Patsch W, Tyroler HA, Wu K, Heiss G
JournalArterioscler Thromb
Volume13
Issue6
Pagination826-33
Date Published1993 Jun
ISSN1049-8834
KeywordsAfrican Continental Ancestry Group, Arteriosclerosis, Carotid Arteries, Cholesterol, LDL, European Continental Ancestry Group, Female, Humans, Lipoprotein(a), Male, Middle Aged, Prospective Studies, Risk Factors
Abstract

Elevated mean levels of lipoprotein[a] (Lp[a]) have been associated with symptomatic cardiovascular diseases such as clinically manifest myocardial infarction (MI), coronary artery disease, restenosis of coronary artery vein grafts after bypass, and a family history of MI. Associations of Lp[a] with arterial wall thickening in asymptomatic individuals previously have not been addressed and are evaluated in this report among participants of the Atherosclerosis Risk in Communities (ARIC) Study. Intima-media wall thickening in the extracranial carotid arteries was assessed noninvasively with B-mode ultrasonography; Lp[a] was measured as its total protein component. Individuals with wall thickening > or = 90th percentile of the population maximum far-wall thickness were pair matched to participants

DOI10.1161/01.atv.13.6.826
Alternate JournalArterioscler Thromb
PubMed ID8499402
Grant List1-HC-55019 / HC / NHLBI NIH HHS / United States