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Lipoprotein[a] as a risk factor for preclinical atherosclerosis.

TitleLipoprotein[a] as a risk factor for preclinical atherosclerosis.
Publication TypeJournal Article
Year of Publication1993
AuthorsSchreiner PJ, Morrisett JD, Sharrett AR, Patsch W, Tyroler HA, Wu K, Heiss G
JournalArterioscler Thromb
Date Published1993 Jun
KeywordsAfrican Continental Ancestry Group, Arteriosclerosis, Carotid Arteries, Cholesterol, LDL, European Continental Ancestry Group, Female, Humans, Lipoprotein(a), Male, Middle Aged, Prospective Studies, Risk Factors

Elevated mean levels of lipoprotein[a] (Lp[a]) have been associated with symptomatic cardiovascular diseases such as clinically manifest myocardial infarction (MI), coronary artery disease, restenosis of coronary artery vein grafts after bypass, and a family history of MI. Associations of Lp[a] with arterial wall thickening in asymptomatic individuals previously have not been addressed and are evaluated in this report among participants of the Atherosclerosis Risk in Communities (ARIC) Study. Intima-media wall thickening in the extracranial carotid arteries was assessed noninvasively with B-mode ultrasonography; Lp[a] was measured as its total protein component. Individuals with wall thickening > or = 90th percentile of the population maximum far-wall thickness were pair matched to participants

Alternate JournalArterioscler Thromb
PubMed ID8499402
Grant List1-HC-55019 / HC / NHLBI NIH HHS / United States