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Sex difference in high density lipoprotein cholesterol in six countries.

TitleSex difference in high density lipoprotein cholesterol in six countries.
Publication TypeJournal Article
Year of Publication1996
AuthorsDavis CE, Williams DH, Oganov RG, Tao SC, Rywik SL, Stein Y, Little JA
JournalAm J Epidemiol
Date Published1996 Jun 01
KeywordsArteriosclerosis, Canada, China, Cholesterol, HDL, Confounding Factors, Epidemiologic, Female, Humans, Israel, Male, Middle Aged, Poland, Population Surveillance, Russia, Sex Characteristics, United States

It is known that women have higher levels of high density lipoprotein (HDL) cholesterol than men. The authors examined the association between HDL cholesterol and biologic sex in 8,631 women and 10,690 men aged 45-54 years from six countries studied between 1972 and 1989. The variation in the sex difference for HDL cholesterol was significant; the smallest difference (0.06 mmol/liter) was seen in China and the largest (0.40 mmol/liter) in Canada. Adjustment for differences in body mass index, smoking, alcohol use, and heart rate reduced but did not eliminate the variability. The sex difference in HDL cholesterol levels, usually assumed to be due to biologic factors, differs across cultures and may be related to environmental factors.

Alternate JournalAm J Epidemiol
PubMed ID8633598
Grant ListN01-HV-08112 / HV / NHLBI NIH HHS / United States