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Association of vagal tone with serum insulin, glucose, and diabetes mellitus--The ARIC Study.

TitleAssociation of vagal tone with serum insulin, glucose, and diabetes mellitus--The ARIC Study.
Publication TypeJournal Article
Year of Publication1995
AuthorsLiao D, Cai J, Brancati FL, Folsom A, Barnes RW, Tyroler HA, Heiss G
JournalDiabetes Res Clin Pract
Date Published1995 Dec
KeywordsBlood Glucose, Cohort Studies, Diabetes Mellitus, Fasting, Female, Follow-Up Studies, Heart Rate, Humans, Insulin, Longitudinal Studies, Male, Middle Aged, Parasympathetic Nervous System, Prospective Studies, Radioimmunoassay, Reference Values, United States, Vagus Nerve

Reduced vagal activity assessed by heart rate variability (HRV) has been observed in studies of diabetics, but this association has not been reported at the population level. To investigate the association of HRV with diabetes mellitus, as well as fasting serum insulin, and glucose, we examined a stratified random sample of 1933 individuals (154 diabetics and 1779 non-diabetics), aged 45-65 years from the Atherosclerosis Risk in Communities (ARIC) study cohort. Two-minute, resting, supine beat-to-beat heart rate records were collected. Power spectral density estimation was used to derive HRV high frequency power (HF, 0.15-0.35 Hz) as the conventional marker of vagal function. Age, race, and gender-adjusted geometric means of HF were 0.78 and 1.27 (beat/min)(2) for diabetics and non-diabetics respectively (P for mean difference

Alternate JournalDiabetes Res Clin Pract
PubMed ID8861461
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States