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Variability in B-mode ultrasound measurements in the atherosclerosis risk in communities (ARIC) study.

TitleVariability in B-mode ultrasound measurements in the atherosclerosis risk in communities (ARIC) study.
Publication TypeJournal Article
Year of Publication1996
AuthorsChambless LE, Zhong MM, Arnett D, Folsom AR, Riley WA, Heiss G
JournalUltrasound Med Biol
Date Published1996
KeywordsAnalysis of Variance, Arteriosclerosis, Carotid Arteries, Humans, Middle Aged, Prospective Studies, Reproducibility of Results, Tunica Intima, Ultrasonography, United States

The Atherosclerosis Risk in Communities (ARIC) study is a multicenter, long-term epidemiologic study that uses B-mode ultrasound primarily to measure carotid arterial intima-media wall thickness. To assess the reliability of the measurement process of this application of B-mode technology to population-based research, 36 volunteers from four centers were scanned at three visits, 7-14 days apart. Estimates of the components of variation in the B-mode measurements of artery wall thickness from between-person, between-sonographer, within-sonographer, between-reader and within-reader variation are presented, along with estimates of the correlation R between measures made at repeat visits by different sonographers and read by different readers. The estimates of R for mean intima-media thickness are 0.69, 0.60, 0.54 and 0.66 for the carotid bifurcation, internal carotid, common carotid, and three-segment overall carotid mean, respectively. When these are adjusted to account for differences in between-person variance between the ancillary study and the main ARIC study, the estimated site-specific reliability coefficients appropriate to the ARIC study population are 0.77, 0.73 and 0.70 for mean carotid far-wall intima-media thickness at the carotid bifurcation and the internal and common carotid arteries.

Alternate JournalUltrasound Med Biol
PubMed ID8865551
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States