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Correlates of uric acid and its association with asymptomatic carotid atherosclerosis: the ARIC Study. Atherosclerosis Risk in Communities.

TitleCorrelates of uric acid and its association with asymptomatic carotid atherosclerosis: the ARIC Study. Atherosclerosis Risk in Communities.
Publication TypeJournal Article
Year of Publication1996
AuthorsIribarren C, Folsom AR, Eckfeldt JH, McGovern PG, Nieto FJ
JournalAnn Epidemiol
Volume6
Issue4
Pagination331-40
Date Published1996 Jul
ISSN1047-2797
KeywordsAfrican Continental Ancestry Group, Age Distribution, Analysis of Variance, Arteriosclerosis, Carotid Stenosis, Cohort Studies, Cross-Sectional Studies, Databases, Factual, European Continental Ancestry Group, Female, Health Status Indicators, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Risk Factors, Sampling Studies, Sex Distribution, United States, Uric Acid
Abstract

The correlates of serum uric acid and the association of uric acid with carotid intimal-medial thickness (an early measure of atherosclerosis) were investigated in participants of the baseline examination of the Atherosclerosis Risk in Communities (ARIC) Study. The study sample included 6522 women (74% white) and 4966 men (79% white) who were aged 45 to 64 years at baseline (1986-1989). Those with prevalent coronary heart disease or previous stroke and those taking uricosuric medication were excluded. The mean (SD) uric acid concentration was 5.9 (1.5) mg/dL. It was highest among black men 45-54 years old (6.9 [1.5] mg/dL), and lowest in white women aged 45-54 years old (5.0 [1.2] mg/dL). The uric acid level was positively correlated in both sexes with a variety of health-related factors, most notably body mass index, creatinine, triglycerides, diuretic use, alcohol intake, hypertension, diabetes, and insulin levels. In a linear regression model adjusting for age and ARIC center, the level of uric acid was directly and significantly associated with B-mode ultrasound carotid intimal-medial thickness in women and white men (but not in black men). However, when known risk factors for atherosclerotic disease and relevant behavioral and biological correlates of uric acid were controlled for in multivariate analysis, the association of uric acid with this early measure of atherosclerosis became negligible in white women and much weaker and not statistically significant in black women and white men. Thus, uric acid itself may not be a risk factor for atherosclerosis. Future analysis of cardiovascular events in the ARIC Study will further elucidate the role of uric acid in atherosclerotic disease.

DOI10.1016/s1047-2797(96)00052-x
Alternate JournalAnn Epidemiol
PubMed ID8876844
Grant ListN0-HC-55015 / HC / NHLBI NIH HHS / United States
N0-HC-55016 / HC / NHLBI NIH HHS / United States
N0-HC-55018 / HC / NHLBI NIH HHS / United States