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Changes in plasma lipids and lipoproteins associated with starting or stopping postmenopausal hormone replacement therapy. Atherosclerosis Risk in Communities Study.

TitleChanges in plasma lipids and lipoproteins associated with starting or stopping postmenopausal hormone replacement therapy. Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication1996
AuthorsFolsom AR, McGovern PG, Nabulsi AA, Shahar E, Kahn ES, Winkhart SP, White AD
JournalAm Heart J
Volume132
Issue5
Pagination952-8
Date Published1996 Nov
ISSN0002-8703
KeywordsApolipoproteins B, Arteriosclerosis, Cholesterol, HDL, Cholesterol, LDL, Estrogen Replacement Therapy, Female, Humans, Lipids, Lipoproteins, Middle Aged, Postmenopause, Prospective Studies
Abstract

The Atherosclerosis Risk in Communities Study investigators examined nearly 4000 postmenopausal women from 1987 through 1989 and 3 years later to determine changes in plasma lipids occurring with the starting or stopping of hormone replacement therapy. Women who started estrogen plus progestin therapy (n = 74) had decreases of 9.8 mg/dl in low-density lipoprotein (LDL) cholesterol and 5.8 mg/dl in apolipoprotein B and increases of 1.2 mg/dl in high-density lipoprotein (HDL) cholesterol (HDL change not significant), 13.5 mg/dl in apolipoprotein A-I, and 14.0 mg/dl in triglycerides. Women who started estrogen alone (n = 149) had similar changes, except for a much larger increase in HDL cholesterol (5.8 mg/dl), principally in HDL-2. Women who stopped hormone therapy (n = 138) had lipid changes opposite to those who started therapy, but smaller in magnitude. These results confirm those of the Postmenopausal Estrogen/Progestin Interventions Trial in a community-based longitudinal cohort: women initiating estrogen plus progestin therapy have decreases in LDL cholesterol, but the increase in HDL cholesterol is less than that for starting estrogen alone. In addition, the current study extends findings to apolipoproteins and HDL subfractions.

DOI10.1016/s0002-8703(96)90004-6
Alternate JournalAm Heart J
PubMed ID8892766
Grant ListN01-HL-55015 / HL / NHLBI NIH HHS / United States
N01-HL-55016 / HL / NHLBI NIH HHS / United States
N01-HL-55018 / HL / NHLBI NIH HHS / United States