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Polymorphism of the apolipoprotein B gene and blood lipid concentrations in Japanese and Caucasian population samples.

TitlePolymorphism of the apolipoprotein B gene and blood lipid concentrations in Japanese and Caucasian population samples.
Publication TypeJournal Article
Year of Publication1996
AuthorsIso H, Harada S, Shimamoto T, Folsom AR, Koike K, Sato S, Iida M, Komachi Y
JournalAtherosclerosis
Volume126
Issue2
Pagination233-41
Date Published1996 Oct 25
ISSN0021-9150
KeywordsAged, Alleles, Apolipoproteins B, Asian Continental Ancestry Group, Cholesterol, European Continental Ancestry Group, Female, Gene Frequency, Genotype, Humans, Japan, Lipids, Male, Middle Aged, Minnesota, Polymerase Chain Reaction, Polymorphism, Genetic
Abstract

To examine whether a racial difference in apolipoprotein B (Apo B) gene polymorphism between Japanese and American Caucasians corresponds with the lower blood cholesterol concentrations in Japanese than in Americans, we examined the EcoRI polymorphism of the Apo B gene for 271 nonsmoking men and women aged 47-69 years in two population-based samples: rural Japanese living in Akita and Caucasians living in Minneapolis-St. Paul, Minnesota, USA. Mean values of serum cholesterol concentrations were significantly lower in Japanese than in Caucasians for both men and women (difference = 25-26 mg/dl). An allele-specific polymerase chain reaction was conducted to examine the Eco RI cutting site at the 12669 cDNA position of the Apo B gene. The allele R2 (absence of the cutting site) has been associated with lower cholesterol concentrations in two previous studies. The frequency of the R2 allele was 6% for Japanese and 17% for Caucasians (P

DOI10.1016/0021-9150(96)05912-6
Alternate JournalAtherosclerosis
PubMed ID8902149
Grant ListN01-HC-55019 / HC / NHLBI NIH HHS / United States