Title | Polymorphism of the apolipoprotein B gene and blood lipid concentrations in Japanese and Caucasian population samples. |
Publication Type | Journal Article |
Year of Publication | 1996 |
Authors | Iso H, Harada S, Shimamoto T, Folsom AR, Koike K, Sato S, Iida M, Komachi Y |
Journal | Atherosclerosis |
Volume | 126 |
Issue | 2 |
Pagination | 233-41 |
Date Published | 1996 Oct 25 |
ISSN | 0021-9150 |
Keywords | Aged, Alleles, Apolipoproteins B, Asian People, Cholesterol, Female, Gene Frequency, Genotype, Humans, Japan, Lipids, Male, Middle Aged, Minnesota, Polymerase Chain Reaction, Polymorphism, Genetic, White People |
Abstract | To examine whether a racial difference in apolipoprotein B (Apo B) gene polymorphism between Japanese and American Caucasians corresponds with the lower blood cholesterol concentrations in Japanese than in Americans, we examined the EcoRI polymorphism of the Apo B gene for 271 nonsmoking men and women aged 47-69 years in two population-based samples: rural Japanese living in Akita and Caucasians living in Minneapolis-St. Paul, Minnesota, USA. Mean values of serum cholesterol concentrations were significantly lower in Japanese than in Caucasians for both men and women (difference = 25-26 mg/dl). An allele-specific polymerase chain reaction was conducted to examine the Eco RI cutting site at the 12669 cDNA position of the Apo B gene. The allele R2 (absence of the cutting site) has been associated with lower cholesterol concentrations in two previous studies. The frequency of the R2 allele was 6% for Japanese and 17% for Caucasians (P |
DOI | 10.1016/0021-9150(96)05912-6 |
Alternate Journal | Atherosclerosis |
PubMed ID | 8902149 |
Grant List | N01-HC-55019 / HC / NHLBI NIH HHS / United States |