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Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study.

TitleAssociation between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication1996
AuthorsRÃ¥stam L, Lindberg G, Folsom AR, Burke GL, Nilsson-Ehle P, Lundblad A
JournalInt J Epidemiol
Volume25
Issue5
Pagination953-8
Date Published1996 Oct
ISSN0300-5771
KeywordsArteriosclerosis, Carotid Arteries, Carotid Artery Diseases, Cholesterol, HDL, Cholesterol, LDL, Female, Humans, Hypertension, Insulin, Longitudinal Studies, Male, Middle Aged, N-Acetylneuraminic Acid, Odds Ratio, Risk Factors, Smoking, Ultrasonography
Abstract

BACKGROUND: Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated.

METHODS: From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis.

RESULTS: The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (> or = 78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01-2.70.

CONCLUSION: The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved.

DOI10.1093/ije/25.5.953
Alternate JournalInt J Epidemiol
PubMed ID8921480
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States