Title | Estrogen replacement therapy and cognitive functioning in the Atherosclerosis Risk in Communities (ARIC) Study. |
Publication Type | Journal Article |
Year of Publication | 1996 |
Authors | Szklo M, Cerhan J, Diez-Roux AV, Chambless L, Cooper L, Folsom AR, Fried LP, Knopman D, Nieto FJ |
Journal | Am J Epidemiol |
Volume | 144 |
Issue | 11 |
Pagination | 1048-57 |
Date Published | 1996 Dec 01 |
ISSN | 0002-9262 |
Keywords | Aged, Cognition, Cognition Disorders, Confounding Factors, Epidemiologic, Cross-Sectional Studies, Estrogen Replacement Therapy, Female, Humans, Menopause, Mental Recall, Middle Aged |
Abstract | The association of estrogen replacement therapy (ERT) with cognitive functioning was assessed in 6,110 women aged 48-67 years participating in the Atherosclerosis Risk in Communities (ARIC) study, a multicenter longitudinal investigation. ERT was evaluated in relation to results of three cognitive tests (the Delayed Word Recall (DWR) Test, the Digit Symbol Subtest of the Wechsler Adult intelligence Scale-Revised (DSS/WAIS-R), and the Word Fluency (WF) Test) using data from the first follow-up visit of the cohort (1990-1992). No consistent associations were seen between ERT and either the DWR test or the DSS/WAIS-R after adjusting for age, education, and additional covariates previously found to be associated with cognitive function scores. Among surgically menopausal women aged 48-57 years, adjusted mean WF scores were slightly greater in ERT current users (mean WF 35.9) than in never users (mean WF 33.5) (p |
DOI | 10.1093/oxfordjournals.aje.a008877 |
Alternate Journal | Am J Epidemiol |
PubMed ID | 8942436 |
Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States |