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Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleProspective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication1997
AuthorsFolsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE
JournalCirculation
Volume96
Issue4
Pagination1102-8
Date Published1997 Aug 19
ISSN0009-7322
KeywordsAged, Blood Coagulation Factors, Coronary Disease, Female, Humans, Incidence, Leukocyte Count, Male, Middle Aged, Partial Thromboplastin Time, Platelet Count, Prospective Studies, Risk Factors
Abstract

BACKGROUND: Although hemostatic factors contribute to acute coronary syndromes and atherogenesis, few studies have prospectively evaluated the association between multiple hemostatic factors and coronary heart disease incidence.

METHODS AND RESULTS: The Atherosclerosis Risk in Communities Study recruited 14,477 adults from 45 to 64 years of age who were initially free of coronary heart disease. Coronary disease risk factors and several plasma hemostatic factors were measured, and incidence of coronary heart disease was ascertained during an average follow-up of 5.2 years. Age-, race-, and field center-adjusted relative risks of coronary heart disease were significantly elevated (P

CONCLUSIONS: Elevated levels of fibrinogen, white blood cell count, factor VIII, and von Willebrand factor are risk factors and may play causative roles in coronary heart disease. However, their measurement in healthy adults appears to add little to prediction of coronary events beyond that of more established risk factors.

DOI10.1161/01.cir.96.4.1102
Alternate JournalCirculation
PubMed ID9286936
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States