|Title||Is fasting insulin concentration inversely associated with rate of weight gain? Contrasting findings from the CARDIA and ARIC study cohorts.|
|Publication Type||Journal Article|
|Year of Publication||1998|
|Authors||Folsom AR, Vitelli LL, Lewis CE, Schreiner PJ, Watson RL, Wagenknecht LE|
|Journal||Int J Obes Relat Metab Disord|
|Date Published||1998 Jan|
|Keywords||Adult, Blacks, Cohort Studies, Fasting, Female, Humans, Insulin, Linear Models, Longitudinal Studies, Male, Middle Aged, Sex Factors, Weight Gain, Whites|
OBJECTIVE: To test whether a higher fasting insulin concentration is associated with a lower rate of weight gain over six to seven years.
DESIGN: Two longitudinal epidemiologic cohorts including blacks and whites.
SUBJECTS: The Coronary Artery Risk Development in Young Adults (CARDIA) Study examined subjects aged 18-30 y in 1985-86 and 1992-93 (n = 3636), and the Atherosclerosis Risk in Communities (ARIC) Study examined subjects aged 45-64 y in 1987-89 and 1993-95 (n = 11179).
MEASUREMENTS: In each study, fasting insulin at baseline and weight change during follow-up were measured in participants without diabetes.
RESULTS: In whites and black men in CARDIA, there was a positive age-adjusted association between baseline insulin and weight change, although weight change was not entirely monotonic across the insulin quartiles. In these race-gender groups, the linear regression coefficients indicated that each 50 pmol/L increment of baseline insulin was associated (P
CONCLUSIONS: A higher fasting insulin concentration is associated modestly with a lower rate of weight gain in ARIC, but not in CARDIA.
|Alternate Journal||Int J Obes Relat Metab Disord|
|Grant List||N01-HC-48047 / HC / NHLBI NIH HHS / United States |
N01-HC-48048 / HC / NHLBI NIH HHS / United States
N01-HC-48049 / HC / NHLBI NIH HHS / United States