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Is fasting insulin concentration inversely associated with rate of weight gain? Contrasting findings from the CARDIA and ARIC study cohorts.

TitleIs fasting insulin concentration inversely associated with rate of weight gain? Contrasting findings from the CARDIA and ARIC study cohorts.
Publication TypeJournal Article
Year of Publication1998
AuthorsFolsom AR, Vitelli LL, Lewis CE, Schreiner PJ, Watson RL, Wagenknecht LE
JournalInt J Obes Relat Metab Disord
Volume22
Issue1
Pagination48-54
Date Published1998 Jan
KeywordsAdult, African Continental Ancestry Group, Cohort Studies, European Continental Ancestry Group, Fasting, Female, Humans, Insulin, Linear Models, Longitudinal Studies, Male, Middle Aged, Sex Factors, Weight Gain
Abstract

OBJECTIVE: To test whether a higher fasting insulin concentration is associated with a lower rate of weight gain over six to seven years.

DESIGN: Two longitudinal epidemiologic cohorts including blacks and whites.

SUBJECTS: The Coronary Artery Risk Development in Young Adults (CARDIA) Study examined subjects aged 18-30 y in 1985-86 and 1992-93 (n = 3636), and the Atherosclerosis Risk in Communities (ARIC) Study examined subjects aged 45-64 y in 1987-89 and 1993-95 (n = 11179).

MEASUREMENTS: In each study, fasting insulin at baseline and weight change during follow-up were measured in participants without diabetes.

RESULTS: In whites and black men in CARDIA, there was a positive age-adjusted association between baseline insulin and weight change, although weight change was not entirely monotonic across the insulin quartiles. In these race-gender groups, the linear regression coefficients indicated that each 50 pmol/L increment of baseline insulin was associated (P

CONCLUSIONS: A higher fasting insulin concentration is associated modestly with a lower rate of weight gain in ARIC, but not in CARDIA.

DOI10.1038/sj.ijo.0800542
Alternate JournalInt J Obes Relat Metab Disord
PubMed ID9481599
Grant ListN01-HC-48047 / HC / NHLBI NIH HHS / United States
N01-HC-48048 / HC / NHLBI NIH HHS / United States
N01-HC-48049 / HC / NHLBI NIH HHS / United States