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Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.

TitleProspective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication1998
AuthorsFolsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, Hess DL, Davis CE
JournalCirculation
Volume98
Issue3
Pagination204-10
Date Published1998 Jul 21
ISSN0009-7322
KeywordsArteriosclerosis, Cohort Studies, Coronary Disease, Dietary Supplements, Fasting, Female, Folic Acid, Homocysteine, Humans, Incidence, Male, Middle Aged, Polymorphism, Genetic, Prospective Studies, Pyridoxal Phosphate, Risk Factors, Vitamin B 12
Abstract

BACKGROUND: Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD). More prospective studies are needed.

METHODS AND RESULTS: We used a prospective case-cohort design to determine whether tHcy-related factors are associated with incidence of CHD over an average of 3.3 years of follow-up in a biracial sample of middle-aged men and women. Age-, race-, and field center-adjusted CHD incidence was associated positively (P

CONCLUSIONS: Our prospective findings add uncertainty to conclusions derived mostly from cross-sectional studies that tHcy is a major, independent, causative risk factor for CHD. Our findings point more strongly to the possibility that vitamin B6 offers independent protection. Randomized trials, some of which are under way, are needed to better clarify the interrelationships of tHcy, B vitamins, and cardiovascular disease.

DOI10.1161/01.cir.98.3.204
Alternate JournalCirculation
PubMed ID9697819
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States