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Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study.

TitleIs low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication1998
AuthorsLiao F, Folsom AR, Brancati FL
JournalAm Heart J
Volume136
Issue3
Pagination480-90
Date Published1998 Sep
ISSN0002-8703
KeywordsCoronary Artery Disease, Diet, Electrocardiography, Female, Humans, Magnesium, Male, Maryland, Middle Aged, Minnesota, Mississippi, North Carolina, Prospective Studies, Risk, Risk Factors, Sex Factors
Abstract

BACKGROUND: Hypomagnesemia has been hypothesized to play a role in coronary heart disease (CHD), but few prospective epidemiologic studies have been conducted.

METHODS AND RESULTS: We examined the relation of serum and dietary magnesium with CHD incidence in a sample of middle-aged adults (n=13,922 free of baseline CHD) from 4 US communities. Over 4 to 7 years of follow-up, 223 men and 96 women had CHD develop. After adjustment for sociodemographic characteristics, waist/hip ratio, smoking, alcohol consumption, sports participation, use of diuretics, fibrinogen, total and high-density lipoprotein cholesterol levels, triglyceride levels, and hormone replacement therapy, the relative risk of CHD across quartiles of serum magnesium was 1.00, 0.92, 0.48, and 0.44 (P for trend=0.009) among women and 1.00, 1.32, 0.95, and 0.73 (P for trend=0.07) among men. The adjusted relative risk of CHD for the highest versus the lowest quartile of dietary magnesium was 0.69 in men (95% confidence interval 0.45 to 1.05) and 1.32 in women (0.68 to 2.55).

CONCLUSIONS: These findings suggest that low magnesium concentration may contribute to the pathogenesis of coronary atherosclerosis or acute thrombosis.

DOI10.1016/s0002-8703(98)70224-8
Alternate JournalAm Heart J
PubMed ID9736141
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States