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Helicobacter pylori seropositivity and coronary heart disease incidence. Atherosclerosis Risk In Communities (ARIC) Study Investigators.

TitleHelicobacter pylori seropositivity and coronary heart disease incidence. Atherosclerosis Risk In Communities (ARIC) Study Investigators.
Publication TypeJournal Article
Year of Publication1998
AuthorsFolsom AR, Nieto FJ, Sorlie P, Chambless LE, Graham DY
JournalCirculation
Volume98
Issue9
Pagination845-50
Date Published1998 Sep 01
ISSN0009-7322
KeywordsAntibodies, Bacterial, Arteriosclerosis, Cohort Studies, Coronary Disease, Female, Helicobacter Infections, Helicobacter pylori, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Prevalence, Prospective Studies, Risk Factors
Abstract

BACKGROUND: Several epidemiological and clinical reports have suggested seropositivity for Helicobacter pylori may be a risk factor for coronary heart disease. However, there has been no prospective study of this association involving an ethnically diverse sample of middle-aged men and women.

METHODS AND RESULTS: Using a prospective, case-cohort design, we determined H pylori seropositivity in relation to coronary heart disease incidence over a median follow-up period of 3.3 years among middle-aged men and women. There were 217 incident coronary heart disease cases and a cohort sample of 498. We determined H pylori antibody status by measuring IgG antibody to the high-molecular-weight cell-associated proteins of H pylori using a sensitive and specific ELISA. The prevalence of H pylori seropositivity was higher in blacks than whites, in those with less than high school education, in those with lower plasma pyridoxal 5'-phosphate and higher homocyst(e)ine concentrations, in those who did not use vitamin supplements, in those with higher fibrinogen levels, and in those seropositive for cytomegalovirus and herpes simplex type I (all P

CONCLUSIONS: H pylori infection is probably not an important contributor to clinical coronary heart disease events.

DOI10.1161/01.cir.98.9.845
Alternate JournalCirculation
PubMed ID9738638
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States