|Title||Helicobacter pylori seropositivity and coronary heart disease incidence. Atherosclerosis Risk In Communities (ARIC) Study Investigators.|
|Publication Type||Journal Article|
|Year of Publication||1998|
|Authors||Folsom AR, Nieto FJ, Sorlie P, Chambless LE, Graham DY|
|Date Published||1998 Sep 01|
|Keywords||Antibodies, Bacterial, Arteriosclerosis, Cohort Studies, Coronary Disease, Female, Helicobacter Infections, Helicobacter pylori, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Prevalence, Prospective Studies, Risk Factors|
BACKGROUND: Several epidemiological and clinical reports have suggested seropositivity for Helicobacter pylori may be a risk factor for coronary heart disease. However, there has been no prospective study of this association involving an ethnically diverse sample of middle-aged men and women.
METHODS AND RESULTS: Using a prospective, case-cohort design, we determined H pylori seropositivity in relation to coronary heart disease incidence over a median follow-up period of 3.3 years among middle-aged men and women. There were 217 incident coronary heart disease cases and a cohort sample of 498. We determined H pylori antibody status by measuring IgG antibody to the high-molecular-weight cell-associated proteins of H pylori using a sensitive and specific ELISA. The prevalence of H pylori seropositivity was higher in blacks than whites, in those with less than high school education, in those with lower plasma pyridoxal 5'-phosphate and higher homocyst(e)ine concentrations, in those who did not use vitamin supplements, in those with higher fibrinogen levels, and in those seropositive for cytomegalovirus and herpes simplex type I (all P
CONCLUSIONS: H pylori infection is probably not an important contributor to clinical coronary heart disease events.
|Grant List||N01-HC-55015 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States