|Title||Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study.|
|Publication Type||Journal Article|
|Year of Publication||1999|
|Authors||Peacock JM, Folsom AR, Arnett DK, Eckfeldt JH, Szklo M|
|Date Published||1999 Apr|
|Keywords||Confidence Intervals, Female, Humans, Hypertension, Magnesium, Male, Middle Aged, Odds Ratio, Prospective Studies, Risk Factors, Sex Factors, United States|
PURPOSE: To examine the relationship of serum and dietary magnesium (Mg) with incident hypertension. The setting was the Atherosclerosis Risk in Communities (ARIC) Study, which included a biracial cohort, aged 45-64 years, from four U.S. communities.
METHODS: This analysis included 7731 participants (4190 women and 3541 men) free of hypertension at baseline and followed six years. Fasting serum Mg was measured, and usual dietary intake was assessed with a food frequency questionnaire.
RESULTS: After adjustment for age, race, and a number of other risk factors, the odds of incident hypertension across ascending quartiles of serum Mg were 1.0, 0.79, 0.85, and 0.70 in women (p trend = 0.01) and 1.0, 0.87, 0.87, and 0.82 in men (p trend = 0.16). We found no association between dietary Mg intake and incident hypertension. These associations were attenuated after the addition of baseline systolic blood pressure to the models.
CONCLUSIONS: This study suggests that low Mg may play a modest role in the development of hypertension.
|Alternate Journal||Ann Epidemiol|
|Grant List||N01-HC-55015 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States