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Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleRelationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication1999
AuthorsPeacock JM, Folsom AR, Arnett DK, Eckfeldt JH, Szklo M
JournalAnn Epidemiol
Volume9
Issue3
Pagination159-65
Date Published1999 Apr
ISSN1047-2797
KeywordsConfidence Intervals, Female, Humans, Hypertension, Magnesium, Male, Middle Aged, Odds Ratio, Prospective Studies, Risk Factors, Sex Factors, United States
Abstract

PURPOSE: To examine the relationship of serum and dietary magnesium (Mg) with incident hypertension. The setting was the Atherosclerosis Risk in Communities (ARIC) Study, which included a biracial cohort, aged 45-64 years, from four U.S. communities.

METHODS: This analysis included 7731 participants (4190 women and 3541 men) free of hypertension at baseline and followed six years. Fasting serum Mg was measured, and usual dietary intake was assessed with a food frequency questionnaire.

RESULTS: After adjustment for age, race, and a number of other risk factors, the odds of incident hypertension across ascending quartiles of serum Mg were 1.0, 0.79, 0.85, and 0.70 in women (p trend = 0.01) and 1.0, 0.87, 0.87, and 0.82 in men (p trend = 0.16). We found no association between dietary Mg intake and incident hypertension. These associations were attenuated after the addition of baseline systolic blood pressure to the models.

CONCLUSIONS: This study suggests that low Mg may play a modest role in the development of hypertension.

DOI10.1016/s1047-2797(98)00040-4
Alternate JournalAnn Epidemiol
PubMed ID10192647
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States