| Title | Association of nonsteroidal anti-inflammatory drugs and aspirin with cognitive performance in middle-aged adults. |
| Publication Type | Journal Article |
| Year of Publication | 1999 |
| Authors | Peacock JM, Folsom AR, Knopman DS, Mosley TH, Goff DC, Szklo M |
| Journal | Neuroepidemiology |
| Volume | 18 |
| Issue | 3 |
| Pagination | 134-43 |
| Date Published | 1999 |
| ISSN | 0251-5350 |
| Keywords | Aged, Anti-Inflammatory Agents, Aspirin, Cognition, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Wechsler Scales |
| Abstract | OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study. METHODS: Regular use of NSAIDs or aspirin was analyzed in relation to the results of three cognitive tests, the Delayed Word Recall Test, the WAIS-R Digit Symbol Subtest, and the Word Fluency Test. RESULTS: After adjustment for covariates previously found to be associated with cognition in this sample, we found a weak negative association between current use of aspirin and poor Word Recall [OR = 0.84 (95% confidence interval: 0.68-1.04)] and poor Word Fluency [OR = 0.85 (0.70-1.03)]. We found no association between current use of aspirin and Digit Symbol score, nor did we find current NSAID use to be significantly associated with any of the cognitive tests. CONCLUSIONS: This study suggests a modest association, at best, between NSAIDs or aspirin and better cognitive function. |
| DOI | 10.1159/000026205 |
| Alternate Journal | Neuroepidemiology |
| PubMed ID | 10438276 |
| Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States |