|Title||Association of nonsteroidal anti-inflammatory drugs and aspirin with cognitive performance in middle-aged adults.|
|Publication Type||Journal Article|
|Year of Publication||1999|
|Authors||Peacock JM, Folsom AR, Knopman DS, Mosley TH, Goff DC, Szklo M|
|Keywords||Aged, Anti-Inflammatory Agents, Aspirin, Cognition, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Wechsler Scales|
OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.
METHODS: Regular use of NSAIDs or aspirin was analyzed in relation to the results of three cognitive tests, the Delayed Word Recall Test, the WAIS-R Digit Symbol Subtest, and the Word Fluency Test.
RESULTS: After adjustment for covariates previously found to be associated with cognition in this sample, we found a weak negative association between current use of aspirin and poor Word Recall [OR = 0.84 (95% confidence interval: 0.68-1.04)] and poor Word Fluency [OR = 0.85 (0.70-1.03)]. We found no association between current use of aspirin and Digit Symbol score, nor did we find current NSAID use to be significantly associated with any of the cognitive tests.
CONCLUSIONS: This study suggests a modest association, at best, between NSAIDs or aspirin and better cognitive function.
|Grant List||N01-HC-55015 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States