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Arterial stiffness and the development of hypertension. The ARIC study.

TitleArterial stiffness and the development of hypertension. The ARIC study.
Publication TypeJournal Article
Year of Publication1999
AuthorsLiao D, Arnett DK, Tyroler HA, Riley WA, Chambless LE, Szklo M, Heiss G
JournalHypertension
Volume34
Issue2
Pagination201-6
Date Published1999 Aug
ISSN0194-911X
KeywordsAge Factors, Arteries, Blood Pressure, Carotid Artery, Common, Cohort Studies, Continental Population Groups, Data Interpretation, Statistical, Elasticity, Female, Follow-Up Studies, Hemodynamics, Humans, Hypertension, Linear Models, Male, Middle Aged, Obesity, Odds Ratio, Prospective Studies, Risk Factors, Sex Factors, Smoking, Time Factors, Ultrasonography
Abstract

Decreased elasticity in large and medium-sized arteries has been postulated to be associated with cardiovascular diseases. We prospectively examined the relation between arterial elasticity and the development of hypertension over 6 years of follow-up in a cohort of 6992 normotensive men and women aged 45 to 64 years at baseline from the biracial, population-based Atherosclerosis Risk in Communities (ARIC) Study. Arterial elasticity was measured from high-resolution B-mode ultrasound examination of the left common carotid artery as adjusted arterial diameter change (in micrometers, simultaneously adjusted for diastolic blood pressure, pulse pressure, pulse pressure squared, diastolic arterial diameter, and height), Peterson's elastic modulus (in kilopascals), Young's elastic modulus (in kilopascals), and beta stiffness index. Incident hypertension (n=551) was defined as systolic blood pressure >/=160 mm Hg, diastolic blood pressure >/=95 mm Hg, or the use of antihypertensive medication at a follow-up examination conducted every 3 years. The age-, ethnicity-, center-, gender-, education-, smoking-, heart rate-, and obesity-adjusted means (SE) of baseline adjusted arterial diameter change, Peterson's elastic modulus, Young's elastic modulus, and beta stiffness index were 397 (5), 148 (2.0), 787 (12.7), and 11.43 (0.16), respectively, in persons who developed hypertension during follow-up, in contrast to 407 (1), 124 (0.6), 681 (3.7), and 10.34 (0.05), respectively, for persons who did not. The similarly adjusted cumulative incident rates of hypertension from the highest to the lowest quartiles of arterial elasticity were 6.7%, 8.0%, 7.3%, and 9.6%, respectively, when measured by adjusted arterial diameter change (P

DOI10.1161/01.hyp.34.2.201
Alternate JournalHypertension
PubMed ID10454441
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States