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Haemostasis and carotid artery wall thickness in non-insulin dependent diabetes mellitus.

TitleHaemostasis and carotid artery wall thickness in non-insulin dependent diabetes mellitus.
Publication TypeJournal Article
Year of Publication2000
AuthorsMetcalf PA, Folsom AR, Davis CE, Wu KK, Heiss G
JournalDiabetes Res Clin Pract
Volume47
Issue1
Pagination25-35
Date Published2000 Jan
ISSN0168-8227
KeywordsAge Distribution, Carotid Arteries, Carotid Artery Diseases, Diabetes Mellitus, Type 2, Female, Fibrinogen, Hemostasis, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Risk Factors, Sex Distribution
Abstract

The purpose of this study was to examine the associations of carotid artery intima-media wall thickness (IMT) with hemostatic proteins and cardiovascular risk factors (CVRFs) in participants with and without non-insulin dependent diabetes mellitus (NIDDM). IMT measurements were determined by high resolution B-mode ultrasound imaging of the carotid arteries in 921 participants with NIDDM and 11,964 non-diabetic participants aged 45-64 years. Fasting glucose, serum lipids and activated partial thromboplastin time, factor VIII fibrinogen, factor VII, antithrombin III, protein C, and von Willebrand factor measurements were made. Compared to non-diabetic participants, participants with NIDDM had a more adverse pattern of CVRFs and a more procoagulatory profile. Participants with NIDDM had 0.06 mm (8.1%) higher mean IMT compared to non-diabetic participants after adjusting for age and gender (P

DOI10.1016/s0168-8227(99)00092-3
Alternate JournalDiabetes Res Clin Pract
PubMed ID10660218
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States