Title | Haemostasis and carotid artery wall thickness in non-insulin dependent diabetes mellitus. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Metcalf PA, Folsom AR, Davis CE, Wu KK, Heiss G |
Journal | Diabetes Res Clin Pract |
Volume | 47 |
Issue | 1 |
Pagination | 25-35 |
Date Published | 2000 Jan |
ISSN | 0168-8227 |
Keywords | Age Distribution, Carotid Arteries, Carotid Artery Diseases, Diabetes Mellitus, Type 2, Female, Fibrinogen, Hemostasis, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Risk Factors, Sex Distribution |
Abstract | The purpose of this study was to examine the associations of carotid artery intima-media wall thickness (IMT) with hemostatic proteins and cardiovascular risk factors (CVRFs) in participants with and without non-insulin dependent diabetes mellitus (NIDDM). IMT measurements were determined by high resolution B-mode ultrasound imaging of the carotid arteries in 921 participants with NIDDM and 11,964 non-diabetic participants aged 45-64 years. Fasting glucose, serum lipids and activated partial thromboplastin time, factor VIII fibrinogen, factor VII, antithrombin III, protein C, and von Willebrand factor measurements were made. Compared to non-diabetic participants, participants with NIDDM had a more adverse pattern of CVRFs and a more procoagulatory profile. Participants with NIDDM had 0.06 mm (8.1%) higher mean IMT compared to non-diabetic participants after adjusting for age and gender (P |
DOI | 10.1016/s0168-8227(99)00092-3 |
Alternate Journal | Diabetes Res Clin Pract |
PubMed ID | 10660218 |
Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States |