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Trends in plasma cholesterol levels in the atherosclerosis risk in communities (ARIC) study.

TitleTrends in plasma cholesterol levels in the atherosclerosis risk in communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2000
AuthorsSzklo M, Chambless LE, Folsom AR, Gotto A, Nieto FJ, Patsch W, Shimakawa T, Sorlie P, Wijnberg L
JournalPrev Med
Date Published2000 Mar
KeywordsArteriosclerosis, Cholesterol, Cohort Studies, Community Medicine, Cross-Sectional Studies, Female, Health Status, Humans, Hypercholesterolemia, Male, Middle Aged, Prevalence, Prospective Studies, Random Allocation, Risk Factors, United States

BACKGROUND: Data from the Atherosclerosis Risk in Communities (ARIC) cohort study were examined both cross-sectionally and intraindividually to confirm recent findings from population-based studies showing a decline in total cholesterol (TC) levels in the United States.

METHODS: For the cross-sectional analysis, mean plasma TC levels from 15,792 participants aged 45-64 at baseline visit, and who were selected randomly from four U.S. communities, were examined for each year covered by the first cohort visit (1987, 1988, and 1989). Ninety-three percent of the cohort participants returned for the follow-up visit (1990, 1991, and 1992), and were included in the assessment of intraindividual TC trends.

RESULTS: Both mean TC and prevalence of hypercholesterolemia (defined as plasma cholesterol concentration >/=240 mg/dl) consistently declined over the 3 years covered by visit 1 for all age-gender-race groups. For 1987, 1988, and 1989, mean TC values (mg/dl) were, respectively, 220.3, 216.7, and 214.1 (annual average change, -1.4%, P

CONCLUSION: The current study results are consistent with those of previous studies, and confirm the notion that preventive programs appear to be effective in reducing mean population TC levels.

Alternate JournalPrev Med
PubMed ID10684749