|Title||Trends in plasma cholesterol levels in the atherosclerosis risk in communities (ARIC) study.|
|Publication Type||Journal Article|
|Year of Publication||2000|
|Authors||Szklo M, Chambless LE, Folsom AR, Gotto A, Nieto FJ, Patsch W, Shimakawa T, Sorlie P, Wijnberg L|
|Date Published||2000 Mar|
|Keywords||Arteriosclerosis, Cholesterol, Cohort Studies, Community Medicine, Cross-Sectional Studies, Female, Health Status, Humans, Hypercholesterolemia, Male, Middle Aged, Prevalence, Prospective Studies, Random Allocation, Risk Factors, United States|
BACKGROUND: Data from the Atherosclerosis Risk in Communities (ARIC) cohort study were examined both cross-sectionally and intraindividually to confirm recent findings from population-based studies showing a decline in total cholesterol (TC) levels in the United States.
METHODS: For the cross-sectional analysis, mean plasma TC levels from 15,792 participants aged 45-64 at baseline visit, and who were selected randomly from four U.S. communities, were examined for each year covered by the first cohort visit (1987, 1988, and 1989). Ninety-three percent of the cohort participants returned for the follow-up visit (1990, 1991, and 1992), and were included in the assessment of intraindividual TC trends.
RESULTS: Both mean TC and prevalence of hypercholesterolemia (defined as plasma cholesterol concentration >/=240 mg/dl) consistently declined over the 3 years covered by visit 1 for all age-gender-race groups. For 1987, 1988, and 1989, mean TC values (mg/dl) were, respectively, 220.3, 216.7, and 214.1 (annual average change, -1.4%, P
CONCLUSION: The current study results are consistent with those of previous studies, and confirm the notion that preventive programs appear to be effective in reducing mean population TC levels.
|Alternate Journal||Prev Med|