Pulse lineResearch With Heart Logo

Hypertension and arterial stiffness: the Atherosclerosis Risk in Communities Study. ARIC Investigators.

TitleHypertension and arterial stiffness: the Atherosclerosis Risk in Communities Study. ARIC Investigators.
Publication TypeJournal Article
Year of Publication2000
AuthorsArnett DK, Boland LL, Evans GW, Riley W, Barnes R, Tyroler HA, Heiss G
JournalAm J Hypertens
Volume13
Issue4 Pt 1
Pagination317-23
Date Published2000 Apr
ISSN0895-7061
KeywordsAge Distribution, Aged, Arteriosclerosis, Blood Pressure, Brachial Artery, Carotid Arteries, Elasticity, Female, Humans, Hypertension, Male, Middle Aged, Predictive Value of Tests, Risk Factors
Abstract

Our objective was to describe the relationship of arterial stiffness and hypertension in a large, population-based sample of men and women. Hypertension-related increases in arterial stiffness may reflect the distending pressure and/or structural alterations in the artery. Included were 10,712 participants, ages 45 to 64 years, of the Atherosclerosis Risk in Communities Study, free of prevalent cardiovascular disease. Hypertension was classified as systolic or diastolic blood pressure (BP) > or =140/90 mm Hg, respectively, or the current use of antihypertensive medications. Common carotid arterial diameter change was measured using B-mode ultrasound and an electronic device that utilized radio frequency signals to track the motion of the arterial walls. Using statistical models to control for diastolic BP and pulse pressure, arterial diameter change was calculated separately in normotensive/ nonmedicated and medicated hypertensives. Hypertension was associated with a smaller adjusted diameter change (ie, greater stiffness) in comparison to optimal blood pressure (BP

DOI10.1016/s0895-7061(99)00281-2
Alternate JournalAm J Hypertens
PubMed ID10821330
Grant ListN01-HC 55018 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States