|Title||Nontraditional risk factors for coronary heart disease incidence among persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.|
|Publication Type||Journal Article|
|Year of Publication||2000|
|Authors||Saito I, Folsom AR, Brancati FL, Duncan BB, Chambless LE, McGovern PG|
|Journal||Ann Intern Med|
|Date Published||2000 Jul 18|
|Keywords||Apolipoproteins, Body Constitution, Cholesterol, HDL, Coronary Disease, Diabetes Mellitus, Type 2, Factor VIII, Female, Fibrinogen, Follow-Up Studies, Humans, Incidence, Leukocyte Count, Male, Middle Aged, Prospective Studies, Risk Factors, Serum Albumin, von Willebrand Factor|
BACKGROUND: Major risk factors explain much of the excess risk for coronary heart disease produced by diabetes, but nontraditional factors may also relate to incident coronary heart disease.
OBJECTIVE: To examine the association of traditional and nontraditional risk factors with incidence of coronary heart disease in adults with diabetes.
DESIGN: Prospective cohort study.
SETTING: The Atherosclerosis Risk in Communities (ARIC) Study.
PARTICIPANTS: 1676 middle-aged persons who had diabetes but no history of prevalent coronary heart disease.
MEASUREMENTS: Multiple risk factors were recorded at baseline. Follow-up was from 1987 through 1995.
RESULTS: 186 participants developed incident coronary heart disease events during follow-up. As expected, the incidence of coronary heart disease in participants with diabetes was associated positively with traditional risk factors (hypertension, smoking, total cholesterol level, and low high-density lipoprotein [HDL] cholesterol level). After adjustment for sex, age, ethnicity, and ARIC field center, incident coronary heart disease was also significantly associated with waist-to-hip ratio; levels of HDL3 cholesterol, apolipoproteins A-I and B, albumin, fibrinogen, and von Willebrand factor factor VIII activity; and leukocyte count. However, after adjustment for traditional risk factors for coronary heart disease, only levels of albumin, fibrinogen, and von Willebrand factor; factor VIII activity; and leukocyte count remained independently associated with coronary heart disease (P
CONCLUSIONS: Levels of albumin, fibrinogen, and von Willebrand factor; factor VIII activity; and leukocyte count were predictors of coronary heart disease among persons with diabetes. These associations may reflect 1) the underlying inflammatory reaction or microvascular injury related to atherosclerosis and a tendency toward thrombosis or 2) common antecedents for both diabetes and coronary heart disease.
|Alternate Journal||Ann Intern Med|
|Grant List||N01-HC-55015 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States