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Parental history of stroke predicts subclinical but not clinical stroke: the Atherosclerosis Risk in Communities Study.

TitleParental history of stroke predicts subclinical but not clinical stroke: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2000
AuthorsMorrison AC, Fornage M, Liao D, Boerwinkle E
JournalStroke
Volume31
Issue9
Pagination2098-102
Date Published2000 Sep
ISSN1524-4628
KeywordsAge Factors, Brain, Brain Infarction, Ethnic Groups, Female, Genetic Predisposition to Disease, Humans, Incidence, Interviews as Topic, Magnetic Resonance Imaging, Male, Medical History Taking, Middle Aged, Parents, Prospective Studies, Risk Factors, Sex Factors, Socioeconomic Factors, Stroke, United States
Abstract

BACKGROUND AND PURPOSE: An individual with a positive family history of a disease may be at increased risk for the disease. We sought to examine whether parental history of stroke is associated with subclinical or clinical stroke in the Atherosclerosis Risk in Communities (ARIC) Study, and whether any observed association is independent of established stroke risk factors.

METHODS: Parental history of stroke was determined by home interview at the baseline examination. Cerebral MRI was performed on individuals from 2 ARIC field centers. Subclinical cerebral infarct cases (n=202) were defined by the presence of cerebral infarcts >3 mm. The comparison group for the subclinical cases included all individuals participating in the MRI examination who were not identified as a subclinical case (n=1533). Incidence of clinical ischemic stroke was determined by following the ARIC cohort for potential cerebrovascular events. Two hundred sixty-one validated ischemic strokes were identified; 13 775 individuals from the ARIC cohort did not experience an ischemic event.

RESULTS: Parental history of stroke was significantly associated with subclinical stroke after adjusting for age, gender, and race (OR 1.67, 95% CI1.23 to 2.26) and after further adjustment for multiple stroke risk factors (OR1. 64, 95% CI1.20 to 2.24). Parental history of stroke was not a significant predictor of clinical stroke in either adjustment model.

CONCLUSIONS: The observed increased risk of subclinical stroke among individuals with a parental history of stroke is consistent with the expression of genetic susceptibility, a shared environment, or both in the etiology of stroke. This effect did not appear to be mediated by established stroke risk factors. Parental history of stroke does not confer an increased risk of clinical stroke in this sample of middle-aged Americans.

DOI10.1161/01.str.31.9.2098
Alternate JournalStroke
PubMed ID10978036
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States