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"New" risk factors for atherosclerotic diseases.

Title"New" risk factors for atherosclerotic diseases.
Publication TypeJournal Article
Year of Publication1999
AuthorsFolsom AR
JournalExp Gerontol
Volume34
Issue4
Pagination483-90
Date Published1999 Jul
ISSN0531-5565
KeywordsArteriosclerosis, Genetic Markers, Hemostasis, Homocysteine, Humans, Infections, Inflammation, Insulin Resistance, Risk Factors, Vitamin B Complex
Abstract

Many potential "new" risk factors may predispose to atherosclerotic diseases. The most promising currently seem to be fibrinogen, C-reactive protein and other inflammatory markers; hyperhomocysteinemia; low vitamin E intake; insulin resistance; lipoprotein(a); and fetal undernutrition. However, clinical trial proof of a causal role between several of these risk factors and CHD may be difficult to obtain unless selective interventions are developed to lower them. Certainly, current emphasis for primary and secondary prevention needs to focus on the established risk factors, particularly those for which clinical trial evidence has demonstrated interventions are efficacious for CHD prevention.

DOI10.1016/s0531-5565(98)00075-8
Alternate JournalExp Gerontol
PubMed ID11012298