Pulse lineResearch With Heart Logo

Cardiovascular risk factors and cognitive decline in middle-aged adults.

TitleCardiovascular risk factors and cognitive decline in middle-aged adults.
Publication TypeJournal Article
Year of Publication2001
AuthorsKnopman D, Boland LL, Mosley T, Howard G, Liao D, Szklo M, McGovern P, Folsom AR
Corporate AuthorsAtherosclerosis Risk in Communities(ARIC) Study Investigators
Date Published2001 Jan 09
KeywordsAdult, Aged, Aging, Alzheimer Disease, Arteriosclerosis, Cognition Disorders, Cohort Studies, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Hypertension, Longitudinal Studies, Male, Risk Factors, Wechsler Scales

OBJECTIVE: To perform serial neuropsychological assessments to detect vascular risk factors for cognitive decline in the Atherosclerosis Risk in Communities cohort, a large biracial, multisite, longitudinal investigation of initially middle-aged individuals.

METHODS: The authors administered cognitive assessments to 10,963 individuals (8,729 white individuals and 2,234 black individuals) on two occasions separated by 6 years. Subjects ranged in age at the first assessment from 47 to 70 years. The cognitive assessments included the delayed word recall (DWR) test, a 10-word delayed free recall task in which the learning phase included sentence generation with the study words, the digit symbol subtest (DSS) of the Wechsler Adult Intelligence Scale-Revised and the first-letter word fluency (WF) test using letters F, A, and S.

RESULTS: In multivariate analyses (controlling for demographic factors), the presence of diabetes at baseline was associated with greater decline in scores on both the DSS and WF (p

CONCLUSIONS: Hypertension and diabetes mellitus were positively associated with cognitive decline over 6 years in this late middle-aged population. Interventions aimed at hypertension or diabetes that begin before age 60 might lessen the burden of cognitive impairment in later life.

Alternate JournalNeurology
PubMed ID11148234
Grant ListN01-HL55015 / HL / NHLBI NIH HHS / United States
N01-HL55016 / HL / NHLBI NIH HHS / United States
N01-HL55018 / HL / NHLBI NIH HHS / United States
N01-HL55019 / HL / NHLBI NIH HHS / United States
N01-HL55020 / HL / NHLBI NIH HHS / United States
N01-HL55021 / HL / NHLBI NIH HHS / United States
N01-HL55022 / HL / NHLBI NIH HHS / United States