|Title||Cardiovascular risk factors and cognitive decline in middle-aged adults.|
|Publication Type||Journal Article|
|Year of Publication||2001|
|Authors||Knopman D, Boland LL, Mosley T, Howard G, Liao D, Szklo M, McGovern P, Folsom AR|
|Corporate Authors||Atherosclerosis Risk in Communities(ARIC) Study Investigators|
|Date Published||2001 Jan 09|
|Keywords||Adult, Aged, Aging, Alzheimer Disease, Arteriosclerosis, Cognition Disorders, Cohort Studies, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Hypertension, Longitudinal Studies, Male, Risk Factors, Wechsler Scales|
OBJECTIVE: To perform serial neuropsychological assessments to detect vascular risk factors for cognitive decline in the Atherosclerosis Risk in Communities cohort, a large biracial, multisite, longitudinal investigation of initially middle-aged individuals.
METHODS: The authors administered cognitive assessments to 10,963 individuals (8,729 white individuals and 2,234 black individuals) on two occasions separated by 6 years. Subjects ranged in age at the first assessment from 47 to 70 years. The cognitive assessments included the delayed word recall (DWR) test, a 10-word delayed free recall task in which the learning phase included sentence generation with the study words, the digit symbol subtest (DSS) of the Wechsler Adult Intelligence Scale-Revised and the first-letter word fluency (WF) test using letters F, A, and S.
RESULTS: In multivariate analyses (controlling for demographic factors), the presence of diabetes at baseline was associated with greater decline in scores on both the DSS and WF (p
CONCLUSIONS: Hypertension and diabetes mellitus were positively associated with cognitive decline over 6 years in this late middle-aged population. Interventions aimed at hypertension or diabetes that begin before age 60 might lessen the burden of cognitive impairment in later life.
|Grant List||N01-HL55015 / HL / NHLBI NIH HHS / United States |
N01-HL55016 / HL / NHLBI NIH HHS / United States
N01-HL55018 / HL / NHLBI NIH HHS / United States
N01-HL55019 / HL / NHLBI NIH HHS / United States
N01-HL55020 / HL / NHLBI NIH HHS / United States
N01-HL55021 / HL / NHLBI NIH HHS / United States
N01-HL55022 / HL / NHLBI NIH HHS / United States