Pulse lineResearch With Heart Logo

Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease: the Atherosclerosis Risk in Communities (ARIC) study.

TitleInteraction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease: the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2001
AuthorsLi R, Folsom AR, Sharrett AR, Couper D, Bray M, Tyroler HA
JournalAtherosclerosis
Volume154
Issue3
Pagination729-38
Date Published2001 Feb 15
ISSN0021-9150
KeywordsArteriosclerosis, Cross-Sectional Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Glutathione Transferase, Humans, Leg, Male, Middle Aged, Odds Ratio, Risk Factors, Smoking
Abstract

Glutathione S-transferases M1 or T1 (GSTM1/GSTT1) affect the body's ability either to detoxify or to activate chemicals in cigarette smoke. Cigarette smoking increases the risk of lower extremity arterial disease (LEAD). We conducted a cross-sectional study to evaluate a hypothesized interaction of the genetic polymorphisms of GSTM1 and T1 with cigarette smoking in the risk of LEAD in the ARIC study. A stratified-random sample, including 212 LEAD cases (ankle-brachial index

DOI10.1016/s0021-9150(00)00582-7
Alternate JournalAtherosclerosis
PubMed ID11257276
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States