| Title | Beta-fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: the Atherosclerosis Risk in Communities (ARIC) Study. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Folsom AR, Aleksic N, Ahn C, Boerwinkle E, Wu KK |
| Journal | Ann Epidemiol |
| Volume | 11 |
| Issue | 3 |
| Pagination | 166-70 |
| Date Published | 2001 Apr |
| ISSN | 1047-2797 |
| Keywords | Adenine, Alleles, Arteriosclerosis, Cohort Studies, Coronary Disease, Fibrinogen, Genotype, Guanine, Humans, Incidence, Male, Middle Aged, Polymorphism, Genetic, Prospective Studies, Risk Factors, United States |
| Abstract | PURPOSE: The -455G/A (HaeIII) polymorphism of the beta-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease. METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -455G/A status with a random sample of the cohort (n = 498). RESULTS: Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD. CONCLUSIONS: Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD. |
| DOI | 10.1016/s1047-2797(00)00203-9 |
| Alternate Journal | Ann Epidemiol |
| PubMed ID | 11293402 |
| Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States |