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Acoustic shadowing on B-mode ultrasound of the carotid artery predicts CHD.

TitleAcoustic shadowing on B-mode ultrasound of the carotid artery predicts CHD.
Publication TypeJournal Article
Year of Publication2001
AuthorsHunt KJ, Sharrett AR, Chambless LE, Folsom AR, Evans GW, Heiss G
JournalUltrasound Med Biol
Volume27
Issue3
Pagination357-65
Date Published2001 Mar
ISSN0301-5629
KeywordsCalcinosis, Carotid Arteries, Carotid Artery Diseases, Coronary Disease, Female, Humans, Male, Middle Aged, Observer Variation, Proportional Hazards Models, Prospective Studies, Risk Factors, Ultrasonography
Abstract

The relationship between carotid artery lesions (CALs), with and without acoustic shadowing (AS) as an index of arterial mineralization, and incident coronary heart disease (CHD) was examined in the Atherosclerosis Risk in Communities study cohort. Among 12,375 individuals, ages 45-64 years, free of CHD at baseline, 399 CHD events occurred between 1987-1995. In a 3-cm segment centered at the carotid bifurcation, CALs with and without AS were identified by B-mode ultrasound (US). After adjustment for the major CHD risk factors, the CHD hazard ratio (HR) for women with CAL without AS compared to women without CAL was 1.78 (95% CI: 1.22, 2.60) and the HR comparing women with CAL with AS to women with CAL without AS was 1.73 (95% CI: 1.07, 2.80). Corresponding HRs for men were 1.59 (95% CI: 1.22, 2.07) and 1.04 (95% CI: 0.72, 1.51). CALs predicted CHD events; this association was stronger for mineralized CALs in women, but not men.

DOI10.1016/s0301-5629(00)00353-7
Alternate JournalUltrasound Med Biol
PubMed ID11369121
Grant List5T32-HL07055 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States