Pulse lineResearch With Heart Logo

Ankle-brachial index and 7-year ischemic stroke incidence: the ARIC study.

TitleAnkle-brachial index and 7-year ischemic stroke incidence: the ARIC study.
Publication TypeJournal Article
Year of Publication2001
AuthorsTsai AW, Folsom AR, Rosamond WD, Jones DW
Date Published2001 Aug
KeywordsAfrican Continental Ancestry Group, Blood Pressure, Blood Pressure Determination, Brachial Artery, Brain Ischemia, Cardiovascular Diseases, Cohort Studies, Comorbidity, European Continental Ancestry Group, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Odds Ratio, Predictive Value of Tests, Proportional Hazards Models, Risk Factors, Sex Distribution, Stroke, Systole, Tibial Arteries

BACKGROUND AND PURPOSE: Low ankle-brachial index (ABI), which is the ratio of tibial artery systolic blood pressure to brachial systolic artery pressure, is known to be a measure of lower limb peripheral artery disease as well as a marker for other cardiovascular disease events. The ability of ABI to predict incident ischemic stroke, however, is not established in population-based studies.

METHODS: ABI was measured in a cohort of 14 839 black and white men and women aged 45 to 64 years. Stroke incidence was calculated during approximately 7 years of follow-up.

RESULTS: A total of 206 incident strokes occurred. Adjusted stroke incidence rates were markedly higher for those in the lowest versus the highest categories of ABI for men, women, blacks, and whites. The proportional hazards regression model, adjusted for age, race, gender, and field center, showed an inverse linear trend between ABI and ischemic stroke incidence (P

CONCLUSIONS: Low ABI was strongly associated with increased incidence of ischemic stroke, but the relationship was substantially reduced after adjustment for major cardiovascular risk factors.

Alternate JournalStroke
PubMed ID11486096
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States