Title | Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study. |
Publication Type | Journal Article |
Year of Publication | 2001 |
Authors | Beck JD, Elter JR, Heiss G, Couper D, Mauriello SM, Offenbacher S |
Journal | Arterioscler Thromb Vasc Biol |
Volume | 21 |
Issue | 11 |
Pagination | 1816-22 |
Date Published | 2001 Nov |
ISSN | 1524-4636 |
Keywords | Arteriosclerosis, Carotid Artery Diseases, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Periodontal Diseases, Risk Factors, Tunica Intima, Tunica Media, Ultrasonography |
Abstract | Periodontitis has been linked to clinical cardiovascular disease but not to subclinical atherosclerosis. The purpose of this study was to determine whether periodontitis is associated with carotid artery intima-media wall thickness (IMT). Cross-sectional data on 6017 persons aged 52 to 75 years were obtained from the Atherosclerosis Risk in Communities Study 1996 to 1998 examination. The dependent variable was carotid IMT >/=1 mm. Periodontitis was defined by extent of attachment loss >/=3 mm: none/mild (/=30%). Covariates included age, sex, diabetes, LDL cholesterol, HDL cholesterol, triglycerides, hypertension, smoking, waist-hip ratio, education, and race/study center. Odds of IMT >/=1 mm were higher for severe periodontitis (OR 2.09, 95% CI 1.73 to 2.53) and moderate periodontitis (OR 1.40, CI 1.17 to 1.67) compared with no periodontitis. In a multivariable logistic regression model, severe periodontitis (OR 1.31, CI 1.03 to 1.66) was associated with IMT >/=1 mm, while adjusting for the other factors in the model. These results provide the first indication that periodontitis may play a role in the pathogenesis of atheroma formation, as well as in cardiovascular events. |
DOI | 10.1161/hq1101.097803 |
Alternate Journal | Arterioscler Thromb Vasc Biol |
PubMed ID | 11701471 |
Grant List | R01DE11551 / DE / NIDCR NIH HHS / United States |