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Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study.

TitleRelationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2001
AuthorsBeck JD, Elter JR, Heiss G, Couper D, Mauriello SM, Offenbacher S
JournalArterioscler Thromb Vasc Biol
Volume21
Issue11
Pagination1816-22
Date Published2001 Nov
ISSN1524-4636
KeywordsArteriosclerosis, Carotid Artery Diseases, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Periodontal Diseases, Risk Factors, Tunica Intima, Tunica Media, Ultrasonography
Abstract

Periodontitis has been linked to clinical cardiovascular disease but not to subclinical atherosclerosis. The purpose of this study was to determine whether periodontitis is associated with carotid artery intima-media wall thickness (IMT). Cross-sectional data on 6017 persons aged 52 to 75 years were obtained from the Atherosclerosis Risk in Communities Study 1996 to 1998 examination. The dependent variable was carotid IMT >/=1 mm. Periodontitis was defined by extent of attachment loss >/=3 mm: none/mild (/=30%). Covariates included age, sex, diabetes, LDL cholesterol, HDL cholesterol, triglycerides, hypertension, smoking, waist-hip ratio, education, and race/study center. Odds of IMT >/=1 mm were higher for severe periodontitis (OR 2.09, 95% CI 1.73 to 2.53) and moderate periodontitis (OR 1.40, CI 1.17 to 1.67) compared with no periodontitis. In a multivariable logistic regression model, severe periodontitis (OR 1.31, CI 1.03 to 1.66) was associated with IMT >/=1 mm, while adjusting for the other factors in the model. These results provide the first indication that periodontitis may play a role in the pathogenesis of atheroma formation, as well as in cardiovascular events.

DOI10.1161/hq1101.097803
Alternate JournalArterioscler Thromb Vasc Biol
PubMed ID11701471
Grant ListR01DE11551 / DE / NIDCR NIH HHS / United States