Title | SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Garant MJ, Kao LWH, Brancati F, Coresh J, Rami TM, Hanis CL, Boerwinkle E, Shuldiner AR |
Corporate Authors | Atherosclerosis Risk in Communities Study |
Journal | Diabetes |
Volume | 51 |
Issue | 1 |
Pagination | 231-7 |
Date Published | 2002 Jan |
ISSN | 0012-1797 |
Keywords | Arteriosclerosis, Black People, Blood Glucose, Blood Pressure, Calpain, Cholesterol, HDL, Cholesterol, LDL, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Genetic Variation, Genotype, Humans, Incidence, Insulin, Introns, Male, Middle Aged, Prediabetic State, Prevalence, Risk Factors, Socioeconomic Factors, Triglycerides, United States |
Abstract | Recently, an A-to-G variant in intron 3 (SNP43) of the calcium-activated neutral protease 10 gene (CAPN10) was identified as a possible type 2 diabetes susceptibility gene through positional cloning in Mexican-Americans. We conducted cross-sectional and prospective studies to evaluate the relation between SNP43 and type 2 diabetes and related traits in middle-aged African-American participants of the Atherosclerosis Risk in Communities Study, a population-based longitudinal study. At baseline, 269 prevalent diabetes cases and 1,159 nondiabetic control subjects were studied. Those with the G/G genotype were more likely to have diabetes than those with the A/G or A/A genotype (odds ratio [OR] 1.41, 95% CI 1.00-1.99, P = 0.05). In the prospective study, 166 of the control subjects developed incident diabetes over 9 years of follow-up. The incidence of diabetes for individuals with the G/G genotype did not differ significantly from those with at least one copy of the A allele (23.3 vs. 19.5 per 1,000 person years, P = 0.29). Pooling prevalent and incident diabetic cases together, individuals with the G/G genotype were approximately 40% more likely to have diabetes than those without (OR 1.38, 95% CI 1.04-1.83, P = 0.03). Because of the high frequency of the G allele (0.88), approximately 25% of the susceptibility to type 2 diabetes in African-Americans may be attributed to the G/G genotype at SNP43 of CAPN10, although most of the subjects with the G/G genotype did not develop diabetes over the 9 years of follow-up. We conclude from this large prospective study that the G allele of SNP43 of CAPN10 or another allele or gene that is in linkage disequilibrium with it increases susceptibility to type 2 diabetes in African-Americans. |
DOI | 10.2337/diabetes.51.1.231 |
Alternate Journal | Diabetes |
PubMed ID | 11756346 |
Grant List | 1R01DK53959-01 / DK / NIDDK NIH HHS / United States DK47487 / DK / NIDDK NIH HHS / United States K24 DK02673-01A1 / DK / NIDDK NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States T32HL077024-23 / HL / NHLBI NIH HHS / United States |