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Serum insulin, obesity, and the incidence of type 2 diabetes in black and white adults: the atherosclerosis risk in communities study: 1987-1998.

TitleSerum insulin, obesity, and the incidence of type 2 diabetes in black and white adults: the atherosclerosis risk in communities study: 1987-1998.
Publication TypeJournal Article
Year of Publication2002
AuthorsCarnethon MR, Palaniappan LP, Burchfiel CM, Brancati FL, Fortmann SP
JournalDiabetes Care
Volume25
Issue8
Pagination1358-64
Date Published2002 Aug
ISSN0149-5992
KeywordsAfrican Continental Ancestry Group, Biomarkers, Body Mass Index, Diabetes Mellitus, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Fasting, Female, Humans, Hyperinsulinism, Incidence, Insulin, Male, Middle Aged, Obesity, Predictive Value of Tests, Risk Factors
Abstract

OBJECTIVE: In this study, we tested the hypothesis that fasting serum insulin is higher in nonobese black adults than in white adults and that high fasting insulin predicts type 2 diabetes equally well in both groups.

RESEARCH DESIGN AND METHODS: At the baseline examination (1987-1989) of the Atherosclerosis Risk in Communities Study, fasting insulin and BMI were measured in 13,416 black and white men and women without diabetes. Participants were examined at years 3, 6, and 9 for incident diabetes based on fasting glucose and American Diabetes Association criteria.

RESULTS: Fasting insulin was 19.7 pmol/l higher among nonobese (BMI

CONCLUSIONS: Nonobese black women have higher fasting insulin levels than nonobese white women, and fasting insulin is an equally strong predictor of diabetes in both groups. These results suggest one mechanism to explain the excess incidence of diabetes in nonobese black women but do not explain the excess among black men. Future research should evaluate additional factors: genetic, environmental, or the combination of both, which might explain higher fasting insulin among black women when compared with white women.

DOI10.2337/diacare.25.8.1358
Alternate JournalDiabetes Care
PubMed ID12145235
PubMed Central IDPMC3132185
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
T32 HL007034 / HL / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
F32 HL010338 / HL / NHLBI NIH HHS / United States
R01 DK081371 / DK / NIDDK NIH HHS / United States
5T32HL07034-26 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
R01 DK081371-01A1 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
F32 HL010338-02 / HL / NHLBI NIH HHS / United States