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Impact of body mass index on changes in common carotid artery wall thickness.

TitleImpact of body mass index on changes in common carotid artery wall thickness.
Publication TypeJournal Article
Year of Publication2002
AuthorsStevens J, Cai J, Evans GW
JournalObes Res
Volume10
Issue10
Pagination1000-7
Date Published2002 Oct
ISSN1071-7323
KeywordsAfrican Continental Ancestry Group, Aged, Body Mass Index, Carotid Artery, Common, Cohort Studies, Cross-Sectional Studies, European Continental Ancestry Group, Female, Humans, Longitudinal Studies, Male, Middle Aged, Mississippi, North Carolina, Tunica Intima, Ultrasonography
Abstract

OBJECTIVE: To examine associations between changes in body mass index (BMI) and changes in carotid artery intima-media thickness (IMT) in a community-based sample.

RESEARCH METHODS AND PROCEDURES: Carotid artery IMT and BMI were assessed at baseline (between 1987 and 1990) and in three subsequent examinations at 3-year intervals in participants in the Atherosclerosis Risk in Communities cohort. The 9,316 African-American and white men and women in the analysis were 45 to 64 years of age at baseline. Cross-sectional associations between BMI and IMT were assessed using general linear models. Longitudinal associations were examined using mixed models analysis.

RESULTS: Cross-sectional associations between BMI and IMT were confirmed. At baseline, a 1-kg/m(2) increase in BMI was associated with an increase in IMT that ranged from 2.5 to 7.5 micro m among the ethnic-gender groups examined. Changes in BMI were not associated with changes in IMT in models that adjusted for aging and other covariates. Results were similar across ethnic-gender groups.

DISCUSSION: Among free-living, 45- to 64-year-old adults, changes in common carotid artery IMT associated with changes in BMI are either very small or absent.

DOI10.1038/oby.2002.136
Alternate JournalObes Res
PubMed ID12376580