|Title||Impact of body mass index on changes in common carotid artery wall thickness.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Stevens J, Cai J, Evans GW|
|Date Published||2002 Oct|
|Keywords||African Continental Ancestry Group, Aged, Body Mass Index, Carotid Artery, Common, Cohort Studies, Cross-Sectional Studies, European Continental Ancestry Group, Female, Humans, Longitudinal Studies, Male, Middle Aged, Mississippi, North Carolina, Tunica Intima, Ultrasonography|
OBJECTIVE: To examine associations between changes in body mass index (BMI) and changes in carotid artery intima-media thickness (IMT) in a community-based sample.
RESEARCH METHODS AND PROCEDURES: Carotid artery IMT and BMI were assessed at baseline (between 1987 and 1990) and in three subsequent examinations at 3-year intervals in participants in the Atherosclerosis Risk in Communities cohort. The 9,316 African-American and white men and women in the analysis were 45 to 64 years of age at baseline. Cross-sectional associations between BMI and IMT were assessed using general linear models. Longitudinal associations were examined using mixed models analysis.
RESULTS: Cross-sectional associations between BMI and IMT were confirmed. At baseline, a 1-kg/m(2) increase in BMI was associated with an increase in IMT that ranged from 2.5 to 7.5 micro m among the ethnic-gender groups examined. Changes in BMI were not associated with changes in IMT in models that adjusted for aging and other covariates. Results were similar across ethnic-gender groups.
DISCUSSION: Among free-living, 45- to 64-year-old adults, changes in common carotid artery IMT associated with changes in BMI are either very small or absent.
|Alternate Journal||Obes Res|