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Fibrin fragment D-dimer and the risk of future venous thrombosis.

TitleFibrin fragment D-dimer and the risk of future venous thrombosis.
Publication TypeJournal Article
Year of Publication2003
AuthorsCushman M, Folsom AR, Wang L, Aleksic N, Rosamond WD, Tracy RP, Heckbert SR
JournalBlood
Volume101
Issue4
Pagination1243-8
Date Published2003 Feb 15
ISSN0006-4971
KeywordsAged, Body Mass Index, Cohort Studies, Continental Population Groups, Factor V, Factor VIII, Female, Fibrin Fibrinogen Degradation Products, Humans, Longitudinal Studies, Male, Middle Aged, Odds Ratio, Prospective Studies, Prothrombin, Risk Factors, Venous Thrombosis
Abstract

Plasma D-dimer concentration rises more than 100-fold during acute deep vein thrombosis, but there are no prospective data concerning D-dimer as a risk factor for incident venous thrombosis in a general population. Incident venous thrombosis was ascertained in 2 prospective observational studies, the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Of 21 690 participants enrolled between 1987 and 1993, after 8 years of follow-up, D-dimer was measured using baseline stored plasma of 307 participants who developed venous thrombosis and 616 who did not. Relative to the first quintile of the distribution of D-dimer, the age-adjusted odds ratios for future venous thrombosis for the second to fifth quintiles of D-dimer were 1.6, 2.3, 2.3, and 4.2, respectively (P for trend <.0001 following="" added="" adjustment="" for="" sex="" race="" body="" mass="" index="" factor="" v="" leiden="" prothrombin="" and="" elevated="" viii="" coagulant="" activity="" viii:c="" these="" odds="" ratios="" were="" respectively="" trend="" among="" those="" with="" idiopathic="" thrombosis="" or="" secondary="" unrelated="" to="" cancer="" the="" adjusted="" fifth="" quintile="" respectively.="" by="" contrast="" d-dimer="" in="" versus="" first="" was="" not="" related="" occurrence="" of="" cancer-associated="" ratio="" consistently="" subgroups="" defined="" age="" duration="" follow-up="" type="" vein="" pulmonary="" embolus="" is="" strongly="" positively="" future="" venous="" thrombosis.="">

DOI10.1182/blood-2002-05-1416
Alternate JournalBlood
PubMed ID12393393
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
R01 HL59367 / HL / NHLBI NIH HHS / United States