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Associations of weight loss and changes in fat distribution with the remission of hypertension in a bi-ethnic cohort: the Atherosclerosis Risk in Communities Study.

TitleAssociations of weight loss and changes in fat distribution with the remission of hypertension in a bi-ethnic cohort: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2003
AuthorsStevens J, Chambless LE, Nieto FJ, Jones D, Schreiner P, Arnett D, Cai J
JournalPrev Med
Volume36
Issue3
Pagination330-9
Date Published2003 Mar
ISSN0091-7435
KeywordsAfrican Americans, Age Distribution, Arteriosclerosis, Body Composition, Body Mass Index, Cohort Studies, Comorbidity, Confidence Intervals, European Continental Ancestry Group, Female, Humans, Hypertension, Incidence, Male, Middle Aged, Obesity, Primary Prevention, Proportional Hazards Models, Retrospective Studies, Risk Factors, Sex Distribution, United States, Weight Loss
Abstract

BACKGROUND: To examine associations of weight loss and changes in fat distribution with changes in blood pressure and the remission of hypertension in a community-based sample.

METHODS: Participants were 3245 white and African-American men and women, 45-64 years of age, who participated in the Atherosclerosis Risk in Communities Study over an average of 9 years. Mixed models analyses were used to examine the associations of weight loss and changes in fat distribution with changes in blood pressure. Proportional hazard models with time-dependent covariates were used to examine the associations of weight loss and changes in fat distribution with the remission of hypertension.

RESULTS: Weight loss was associated with a decrease in systolic blood pressure and diastolic blood pressure and with an increased rate of remission of hypertension. Hazard ratios of the remission of hypertension associated with 1-kg increment in annual weight loss were 2.04 (95% confidence interval [CI]: 1.62-2.59), 1.38 (95% CI: 1.14-1.67), 1.84 (95% CI: 1.47-2.29), and 1.53 (95% CI: 1.14-2.05) for white women, African-American women, white men, and African-American men, respectively. Changes in fat distribution were associated with the remission of hypertension in younger (45-54 years) participants.

CONCLUSIONS: Weight loss was associated with a decrease in blood pressure and with remission of hypertension in white and African-American men and women.

DOI10.1016/s0091-7435(02)00063-4
Alternate JournalPrev Med
PubMed ID12634024
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States