|Title||Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Slade GD, Ghezzi EM, Heiss G, Beck JD, Riche E|
|Secondary Authors||Offenbacher S|
|Journal||Arch Intern Med|
|Date Published||2003 May 26|
|Keywords||Acute-Phase Reaction, Aged, Arteriosclerosis, Body Mass Index, C-Reactive Protein, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Periodontal Diseases, Regression Analysis, Risk Factors, United States|
BACKGROUND: Moderately elevated serum C-reactive protein (CRP) concentration is a systemic marker of inflammation and a documented risk factor for cardiovascular disease in otherwise healthy persons. Unrecognized infections, such as periodontal disease, may induce an acute-phase response, elevating CRP levels. We evaluated the association between periodontal disease and CRP levels in adults in the Atherosclerosis Risk in Communities study.
METHODS: Oral examinations were conducted between January 1, 1996, and December 31, 1998, on 5552 ARIC participants (aged 52-74 years) from 4 US communities. Periodontal disease was quantified as the percentage of periodontal sites with pocket depth of 4 mm or more. Serum CRP concentration was quantified in milligrams per liter using an enzyme-linked immunosorbent assay.
RESULTS: Mean (SE) CRP level was 7.6 (0.6) mg/L among people with extensive periodontal pockets (>30% of sites with pocket depth > or =4 mm), approximately one-third greater than that for people with less extensive periodontal pockets (5.7 [0.1] mg/L). In a multivariable linear regression model that controlled for age, sex, diabetes mellitus, cigarette use, and nonsteroidal anti-inflammatory drug use, the association of extensive periodontal pockets with CRP concentration was modified by body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters). For people with a BMI of 20, the model predicted a 2-fold difference in mean CRP concentration between periodontal pocket groups (7.5 vs 3.6 mg/L), but the difference decreased with increasing BMI and was negligible when BMI equaled 35.
CONCLUSIONS: Extensive periodontal disease and BMI are jointly associated with increased CRP levels in otherwise healthy, middle-aged adults, suggesting the need for medical and dental diagnoses when evaluating sources of acute-phase response in some patients.
|Alternate Journal||Arch Intern Med|
|Grant List||DE 00427 / DE / NIDCR NIH HHS / United States |
DE 13079 / DE / NIDCR NIH HHS / United States
RR 00046 / RR / NCRR NIH HHS / United States