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Hepatitis C virus infection and incident type 2 diabetes.

TitleHepatitis C virus infection and incident type 2 diabetes.
Publication TypeJournal Article
Year of Publication2003
AuthorsMehta SH, Brancati FL, Strathdee SA, Pankow JS, Netski D, Coresh J, Szklo M, Thomas DL
Date Published2003 Jul
KeywordsAge Distribution, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Hepatitis C, Humans, Incidence, Male, Middle Aged, Obesity, Prevalence, Proportional Hazards Models, Prospective Studies, Risk Factors, Sex Distribution, United States

Although hepatitis C virus (HCV) infection is more common among adults with type 2 diabetes, it is uncertain whether HCV precedes the development of diabetes. Thus, we performed a prospective (case-cohort) analysis to examine if persons who acquired type 2 diabetes were more likely to have had antecedent HCV infection when enrolled in a community-based cohort of men and women between the ages of 44 and 65 in the United States (Atherosclerosis Risk in Communities Study [ARIC]). Among 1,084 adults free of diabetes at baseline, 548 developed diabetes over 9 years of follow-up evaluation. Incident cases of diabetes were identified by using fasting glucose and medical history and HCV antibodies were assessed at baseline. A priori, persons were categorized as low-risk or high-risk for diabetes based on their age and body mass index, factors that appeared to modify the type 2 diabetes-HCV infection incidence estimates. The overall prevalence of HCV in this population was 0.8%. Among those at high risk for diabetes, persons with HCV infection were more than 11 times as likely as those without HCV infection to develop diabetes (relative hazard, 11.58; 95% confidence interval, 1.39-96.6). Among those at low risk, no increased incidence of diabetes was detected among HCV-infected persons (relative hazard, 0.48; 95% confidence interval, 0.05-4.40). In conclusion, pre-existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Additional larger prospective evaluations are needed to confirm these preliminary findings.

Alternate JournalHepatology
PubMed ID12829986
Grant ListF31 DA06007 / DA / NIDA NIH HHS / United States
N01 HC55020 / HC / NHLBI NIH HHS / United States
R01 DA10627 / DA / NIDA NIH HHS / United States