Title | Hepatitis C virus infection and incident type 2 diabetes. |
Publication Type | Journal Article |
Year of Publication | 2003 |
Authors | Mehta SH, Brancati FL, Strathdee SA, Pankow JS, Netski D, Coresh J, Szklo M, Thomas DL |
Journal | Hepatology |
Volume | 38 |
Issue | 1 |
Pagination | 50-6 |
Date Published | 2003 Jul |
ISSN | 0270-9139 |
Keywords | Age Distribution, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Hepatitis C, Humans, Incidence, Male, Middle Aged, Obesity, Prevalence, Proportional Hazards Models, Prospective Studies, Risk Factors, Sex Distribution, United States |
Abstract | Although hepatitis C virus (HCV) infection is more common among adults with type 2 diabetes, it is uncertain whether HCV precedes the development of diabetes. Thus, we performed a prospective (case-cohort) analysis to examine if persons who acquired type 2 diabetes were more likely to have had antecedent HCV infection when enrolled in a community-based cohort of men and women between the ages of 44 and 65 in the United States (Atherosclerosis Risk in Communities Study [ARIC]). Among 1,084 adults free of diabetes at baseline, 548 developed diabetes over 9 years of follow-up evaluation. Incident cases of diabetes were identified by using fasting glucose and medical history and HCV antibodies were assessed at baseline. A priori, persons were categorized as low-risk or high-risk for diabetes based on their age and body mass index, factors that appeared to modify the type 2 diabetes-HCV infection incidence estimates. The overall prevalence of HCV in this population was 0.8%. Among those at high risk for diabetes, persons with HCV infection were more than 11 times as likely as those without HCV infection to develop diabetes (relative hazard, 11.58; 95% confidence interval, 1.39-96.6). Among those at low risk, no increased incidence of diabetes was detected among HCV-infected persons (relative hazard, 0.48; 95% confidence interval, 0.05-4.40). In conclusion, pre-existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Additional larger prospective evaluations are needed to confirm these preliminary findings. |
DOI | 10.1053/jhep.2003.50291 |
Alternate Journal | Hepatology |
PubMed ID | 12829986 |
Grant List | F31 DA06007 / DA / NIDA NIH HHS / United States N01 HC55020 / HC / NHLBI NIH HHS / United States R01 DA10627 / DA / NIDA NIH HHS / United States |