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A prospective evaluation of the risk of QT prolongation with hormone replacement therapy: the atherosclerosis risk in communities study.

TitleA prospective evaluation of the risk of QT prolongation with hormone replacement therapy: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2003
AuthorsCarnethon MR, Anthony MS, Cascio WE, Folsom AR, Rautaharju PM, Liao D, Evans GW, Heiss G
JournalAnn Epidemiol
Volume13
Issue7
Pagination530-6
Date Published2003 Aug
ISSN1047-2797
KeywordsArteriosclerosis, Cohort Studies, Electrocardiography, Estrogen Replacement Therapy, Female, Humans, Long QT Syndrome, Longitudinal Studies, Middle Aged, Prospective Studies, United States
Abstract

PURPOSE: Prolongation of the QT interval is associated with an increased risk of arrhythmia, coronary heart disease (CHD), and mortality. Estrogens and androgens have been proposed as a causal factor in QT lengthening. We tested whether postmenopausal hormone replacement therapy was associated with prolonged QT intervals in a healthy population sample of women (mean age=54).

METHODS: Women (n=3103) were asked about estrogen (ERT) and progestin plus estrogen (PERT) replacement therapy use at 4 examinations over 9 years. Electrocardiographic QT intervals were measured and corrected for heart rate using the QT Index (QTI) and Bazett's correction. QT prolongation was defined as QTI>110% and a change from baseline of >or=4%.

RESULTS: Heart rate corrected QT length was moderately but significantly (p

CONCLUSIONS: The potential for slight increases in QT length over time, and an increased risk of QT prolongation with ERT use identified in this observational study, are important concerns that should be further explored in randomized trials.

DOI10.1016/s1047-2797(03)00050-4
Alternate JournalAnn Epidemiol
PubMed ID12932629
Grant List5 R01 HL55669 / HL / NHLBI NIH HHS / United States
5T32HL07034-26 / HL / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55105 / HC / NHLBI NIH HHS / United States