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Risk factors for progression to incident hyperinsulinemia: the Atherosclerosis Risk in Communities Study, 1987-1998.

TitleRisk factors for progression to incident hyperinsulinemia: the Atherosclerosis Risk in Communities Study, 1987-1998.
Publication TypeJournal Article
Year of Publication2003
AuthorsCarnethon MR, Fortmann SP, Palaniappan L, Duncan BB, Schmidt MI, Chambless LE
JournalAm J Epidemiol
Volume158
Issue11
Pagination1058-67
Date Published2003 Dec 01
ISSN0002-9262
KeywordsArteriosclerosis, Blood Pressure, Body Mass Index, Cholesterol, Educational Status, Female, Health Behavior, Humans, Hyperinsulinism, Life Style, Longitudinal Studies, Male, Metabolic Syndrome, Middle Aged, Population Surveillance, Risk Factors, United States
Abstract

Hyperinsulinemia is a marker of insulin resistance, a correlate of the metabolic syndrome, and an established precursor of type 2 diabetes. This US study investigated the role of risk factors associated with hyperinsulinemia in cross-sectional studies in progression to incident hyperinsulinemia. Nondiabetic participants from the Atherosclerosis Risk in Communities Study (n = 9,020) were followed from 1987 to 1998 for the development of hyperinsulinemia (fasting serum insulin > or = 90th percentile, 19.1 micro U/ml). After adjustment for demographic characteristics, all risk factors simultaneously, and baseline insulin value, the risk of progressing to hyperinsulinemia increased per standard deviation increase in baseline uric acid (odds ratio (OR) = 1.3, 95% confidence interval (CI): 1.2, 1.4; per 1.4 mg/dl) and waist/hip ratio (OR = 1.4, 95% CI: 1.2, 1.5; per 0.08) and was inversely associated with high density lipoprotein cholesterol (OR = 0.8, 95% CI: 0.7, 0.9; per 0.4 mmol/liter). Starting to smoke (OR = 1.5, 95% CI: 1.2, 2.0) and becoming obese (OR = 2.4, 95% CI: 1.8, 3.1) during the study were also associated with increased risk. The associations were similar across race and gender groups. These data suggest that, in addition to weight gain, hyperuricemia, dyslipidemia, and smoking can be detected prior to development of hyperinsulinemia.

DOI10.1093/aje/kwg260
Alternate JournalAm J Epidemiol
PubMed ID14630601
Grant List5 T32 HL 07034 / HL / NHLBI NIH HHS / United States
F32 HL10338-01 / HL / NHLBI NIH HHS / United States