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Relationship of periodontal disease and edentulism to stroke/TIA.

TitleRelationship of periodontal disease and edentulism to stroke/TIA.
Publication TypeJournal Article
Year of Publication2003
AuthorsElter JR, Offenbacher S, Toole JF, Beck JD
JournalJ Dent Res
Date Published2003 Dec
KeywordsAdult, Confidence Intervals, Confounding Factors, Epidemiologic, Coronary Disease, Cross-Sectional Studies, Female, Humans, Ischemic Attack, Transient, Life Style, Logistic Models, Male, Mouth, Edentulous, Odds Ratio, Periodontal Attachment Loss, Periodontal Diseases, Prevalence, Risk Factors, Sex Factors, Smoking, Stroke, United States

Periodontitis has been shown to increase the systemic inflammatory response, which has been implicated in atherosclerosis and cerebrovascular events. We hypothesized an association between periodontitis or edentulism and Stroke/TIA in the ARIC Study. Data on 9415 dentate and 1491 edentulous adults included demographics, cardiovascular outcomes, lifestyle, laboratory measures, and, for 6436 of the dentate, a dental examination. The dependent variable was Stroke/TIA, and the exposure was extent (%) of attachment level 3+ millimeters (AL). Quartiles of AL and edentulism were compared for Stroke/TIA using odds ratios (OR) and 95% confidence intervals (CI), and confounders were controlled by logistic regression. Stroke/TIA was prevalent in 13.5% of periodontal examinees, 15.6% of dentate non-examinees, and 22.5% of edentulous persons. The highest quartile of AL (OR 1.3, CI 1.02-1.7) and edentulism (OR 1.4, CI 1.5-2.0) were associated with Stroke/TIA.

Alternate JournalJ Dent Res
PubMed ID14630902
Grant ListR01DE 11551 / DE / NIDCR NIH HHS / United States