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Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study.

TitleLung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2003
AuthorsSchroeder EB, Welch V L, Couper D, Nieto JF, Liao D, Rosamond WD, Heiss G
JournalAm J Epidemiol
Volume158
Issue12
Pagination1171-81
Date Published2003 Dec 15
ISSN0002-9262
KeywordsAfrican Americans, Coronary Artery Disease, European Continental Ancestry Group, Female, Forced Expiratory Volume, Humans, Incidence, Male, Middle Aged, Risk Factors, Smoking, United States, Vital Capacity
Abstract

The authors examined the association between lung function, as measured by forced expiratory volume in 1 second (FEV1) and forced vital capacity, and the 10-year incidence of coronary heart disease among 14,480 participants in the Atherosclerosis Risk in Communities Study (1987-1998). Separate proportional hazards models were used for FEV1 and forced vital capacity, with gender-specific lung function quartiles and lung function x gender interaction terms. An association between lung function and coronary heart disease was observed in both genders and was stronger among women. After adjustment for age, race, study center, height, height squared, smoking, and cardiovascular disease risk factors, the hazard ratios for the first (lowest), second, and third quartiles of FEV1 were 3.70 (95% confidence interval (CI): 2.19, 6.24), 2.54 (95% CI: 1.49, 4.32), and 2.25 (95% CI: 1.31, 3.87) for women and 1.51 (95% CI: 1.07, 2.13), 1.59 (95% CI: 1.15, 2.20), and 1.52 (95% CI: 1.10, 2.09) for men. After stratification by smoking status, associations were observed in each smoking group for women, while those in men were weaker and less consistent. Similar results were obtained for forced vital capacity. This analysis indicates an association between lung function and incident coronary heart disease that may be stronger in women than in men.

DOI10.1093/aje/kwg276
Alternate JournalAm J Epidemiol
PubMed ID14652302
Grant List5F-31-HL-09284 / HL / NHLBI NIH HHS / United States
5T-32-HL-07055 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States