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Depressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities study.

TitleDepressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2004
AuthorsGolden S H, Williams JE, Ford DE, Yeh H-C, Paton Sanford C, Nieto JF, Brancati FL
Corporate AuthorsAtherosclerosis Risk in Communities Study
JournalDiabetes Care
Volume27
Issue2
Pagination429-35
Date Published2004 Feb
ISSN0149-5992
KeywordsArteriosclerosis, Blood Chemical Analysis, Body Mass Index, Cohort Studies, Depression, Diabetes Mellitus, Type 2, Female, Humans, Longitudinal Studies, Male, Middle Aged, Racial Groups, Risk Factors, United States
Abstract

OBJECTIVE: The goal of this study was to determine whether depressive symptoms predict type 2 diabetes.

RESEARCH DESIGN AND METHODS: We analyzed data on depressive symptoms (including recent fatigue, sleep disturbance, feelings of hopelessness, loss of libido, and increased irritability) in a longitudinal, biracial cohort study of 11,615 initially nondiabetic adults aged 48-67 years, who were subsequently followed for 6 years for the development of type 2 diabetes.

RESULTS: At baseline, depressive symptoms were positively associated with BMI, fasting insulin, systolic blood pressure, caloric intake, physical inactivity, and current smoking (all P

CONCLUSIONS: In this cohort, depressive symptoms predicted incident type 2 diabetes. This relation is only partially explained by demographic, metabolic, and lifestyle factors. Possible neuroendocrine mediators of the stress-obesity-diabetes relationship require further evaluation in prospective cohort studies that use an established tool to assess depression and incorporate neurohormonal measurements.

DOI10.2337/diacare.27.2.429
Alternate JournalDiabetes Care
PubMed ID14747224
Grant ListIK24-DK-6222-O1 / DK / NIDDK NIH HHS / United States
N01-HC55015 / HC / NHLBI NIH HHS / United States
N01-HC55016 / HC / NHLBI NIH HHS / United States
N01-HC55018 / HC / NHLBI NIH HHS / United States
N01-HC55019 / HC / NHLBI NIH HHS / United States
N01-HC55020 / HC / NHLBI NIH HHS / United States
N01-HC55021 / HC / NHLBI NIH HHS / United States
N01-HC55022 / HC / NHLBI NIH HHS / United States