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Depressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities study.

TitleDepressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2004
AuthorsGolden S H, Williams JE, Ford DE, Yeh H-C, Paton Sanford C, Nieto JF, Brancati FL
Corporate AuthorsAtherosclerosis Risk in Communities Study
JournalDiabetes Care
Volume27
Issue2
Pagination429-35
Date Published2004 Feb
ISSN0149-5992
KeywordsArteriosclerosis, Blood Chemical Analysis, Body Mass Index, Cohort Studies, Continental Population Groups, Depression, Diabetes Mellitus, Type 2, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, United States
Abstract

OBJECTIVE: The goal of this study was to determine whether depressive symptoms predict type 2 diabetes.

RESEARCH DESIGN AND METHODS: We analyzed data on depressive symptoms (including recent fatigue, sleep disturbance, feelings of hopelessness, loss of libido, and increased irritability) in a longitudinal, biracial cohort study of 11,615 initially nondiabetic adults aged 48-67 years, who were subsequently followed for 6 years for the development of type 2 diabetes.

RESULTS: At baseline, depressive symptoms were positively associated with BMI, fasting insulin, systolic blood pressure, caloric intake, physical inactivity, and current smoking (all P

CONCLUSIONS: In this cohort, depressive symptoms predicted incident type 2 diabetes. This relation is only partially explained by demographic, metabolic, and lifestyle factors. Possible neuroendocrine mediators of the stress-obesity-diabetes relationship require further evaluation in prospective cohort studies that use an established tool to assess depression and incorporate neurohormonal measurements.

DOI10.2337/diacare.27.2.429
Alternate JournalDiabetes Care
PubMed ID14747224
Grant ListIK24-DK-6222-O1 / DK / NIDDK NIH HHS / United States
N01-HC55015 / HC / NHLBI NIH HHS / United States
N01-HC55016 / HC / NHLBI NIH HHS / United States
N01-HC55018 / HC / NHLBI NIH HHS / United States
N01-HC55019 / HC / NHLBI NIH HHS / United States
N01-HC55020 / HC / NHLBI NIH HHS / United States
N01-HC55021 / HC / NHLBI NIH HHS / United States
N01-HC55022 / HC / NHLBI NIH HHS / United States