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Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction.

TitleCardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction.
Publication TypeJournal Article
Year of Publication2004
AuthorsLee C D, Folsom AR, Pankow JS, Brancati FL
Corporate AuthorsAtherosclerosis Risk in Communities(ARIC) Study Investigators
JournalCirculation
Volume109
Issue7
Pagination855-60
Date Published2004 Feb 24
ISSN1524-4539
KeywordsAfrican Americans, Cardiovascular Diseases, Carotid Arteries, Cohort Studies, Comorbidity, Diabetes Mellitus, European Continental Ancestry Group, Female, Follow-Up Studies, Humans, Hypercholesterolemia, Hypertension, Life Tables, Male, Middle Aged, Myocardial Infarction, Obesity, Risk, Smoking, Stroke, Survival Analysis, Tunica Intima, Tunica Media, Ultrasonography, United States
Abstract

BACKGROUND: Whether diabetic patients without a history of myocardial infarction (MI) have the same risk of coronary heart disease (CHD) events as nondiabetic patients with a history of MI remains controversial. We compared risks of CHD and stroke events and mortality from cardiovascular disease (CVD) in diabetic and nondiabetic men and women with and without a history of MI.

METHODS AND RESULTS: We followed a total of 13 790 African American and white men and women ages 45 to 64 years who participated in the Atherosclerosis Risk in Communities study, beginning in 1987 to 1989. There were 634 fatal CHD or nonfatal MI events, 312 fatal or nonfatal strokes, and 358 deaths from CVD during an average of 9 years of follow-up (125 998 person-years). After adjustment for age, sex, race, Atherosclerosis Risk in Communities field center, and multiple baseline risk factors, patients who had a history of MI without diabetes at baseline had 1.9 times the risk of fatal CHD or nonfatal MI (95% CI, 1.35 to 2.56; P

CONCLUSIONS: Diabetic patients without MI had lower risk of CHD events and mortality from CVD compared with nondiabetic patients with MI, but stroke risk was similar between these 2 groups.

DOI10.1161/01.CIR.0000116389.61864.DE
Alternate JournalCirculation
PubMed ID14757692
Grant List1K24 DK6222-01 / DK / NIDDK NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
T32-HL07779 / HL / NHLBI NIH HHS / United States