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Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study.

TitleRelation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2004
AuthorsMillen AE, Klein R, Folsom AR, Stevens J, Palta M, Mares JA
JournalAm J Clin Nutr
Volume79
Issue5
Pagination865-73
Date Published2004 May
ISSN0002-9165
KeywordsAntioxidants, Arteriosclerosis, Ascorbic Acid, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Diet, Dietary Supplements, Epidemiologic Studies, Female, Health Surveys, Humans, Male, Middle Aged, Nutrition Surveys, Odds Ratio, Prevalence, Risk Factors, Surveys and Questionnaires, Vitamin E
Abstract

BACKGROUND: The potential protective effect of vitamins C and E against the development of diabetic retinopathy has not been thoroughly evaluated in epidemiologic studies.

OBJECTIVE: The objective was to study the association between prevalent diabetic retinopathy and intake of vitamins C and E in participants of the Atherosclerosis Risk in Communities Study.

DESIGN: A total of 1353 subjects with type 2 diabetes diagnosed between 1993 and 1995 or before were included. Nutrient intake was assessed with a food-frequency and supplement questionnaire administered between 1987-1989 and 1993-1995. Prevalent retinopathy (n = 224) was determined in 1993-1995 from graded fundus photographs.

RESULTS: No association of retinopathy with intake of vitamin C or E from food alone or from food and supplements combined was observed. The odds ratios and 95% CIs for retinopathy for quartile 4 compared with quartile 1 of vitamins C and E intakes from food and supplements combined were 1.1 (0.7, 1.9) and 1.3 (0.8, 2.2), respectively, after adjustment for diabetes treatment and serum glucose. There was a significant interaction of the observed relations with serum glucose concentration (P or =3 y before 1993-1995) of vitamin C or E supplements or multisupplements compared with reported use of no supplements: 0.5 (0.3, 0.8), 0.5 (0.2, 0.8), and 0.4 (0.2, 0.9), respectively.

CONCLUSION: No significant overall associations were observed between risk of retinopathy and intake of major dietary antioxidants. The observed association between risk of retinopathy and supplement use may reflect nondietary factors or a possible benefit of supplementation.

DOI10.1093/ajcn/79.5.865
Alternate JournalAm J Clin Nutr
PubMed ID15113727
Grant ListEY 11722 / EY / NEI NIH HHS / United States