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Synergism between smoking and vital exhaustion in the risk of ischemic stroke: evidence from the ARIC study.

TitleSynergism between smoking and vital exhaustion in the risk of ischemic stroke: evidence from the ARIC study.
Publication TypeJournal Article
Year of Publication2004
AuthorsSchwartz SW, Carlucci C, Chambless LE, Rosamond WD
JournalAnn Epidemiol
Volume14
Issue6
Pagination416-24
Date Published2004 Jul
ISSN1047-2797
KeywordsAged, Brain Ischemia, Effect Modifier, Epidemiologic, Fatigue, Female, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Probability, Risk Assessment, Risk Factors, Smoking, Stroke, Surveys and Questionnaires, United States
Abstract

PURPOSE: To examine the synergism between vital exhaustion and cigarette smoking in producing ischemic stroke. Vital exhaustion (VE), a state characterized by unusual fatigue, irritability, and feelings of demoralization, is measured by the Maastricht questionnaire (MQ), a 21-item inventory of symptoms.

METHODS: The Atherosclerosis Risk in Communities (ARIC) Study is an ongoing cohort study, initiated in 1987. The MQ was administered at the second follow-up visit (1990-1992), and participants were subsequently followed for an average of 6.27 years. Four US communities (Minneapolis, Minnesota; Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi). 13,066 participants aged 48 to 67 years at baseline (Visit 2) with no history of stroke. Validated hospitalized ischemic stroke.

RESULTS: During the follow-up period, there were 202 incident ischemic strokes. After multivariate adjustment, current smoking, and high VE were independent risk factors for incident stroke: (smoking vs. non-smoking HR=1.76, p

CONCLUSIONS: The combination of cigarette smoking and VE is synergistic in the production of stroke.

DOI10.1016/j.annepidem.2003.10.010
Alternate JournalAnn Epidemiol
PubMed ID15246330
Grant ListN01-HL-55015 / HL / NHLBI NIH HHS / United States
N01-HL-55016 / HL / NHLBI NIH HHS / United States
N01-HL-55018 / HL / NHLBI NIH HHS / United States
N01-HL-55019 / HL / NHLBI NIH HHS / United States
N01-HL-55020 / HL / NHLBI NIH HHS / United States
N01-HL-55021 / HL / NHLBI NIH HHS / United States
N01-HL-55022 / HL / NHLBI NIH HHS / United States