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Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study.

TitleAdiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2004
AuthorsDuncan BB, Schmidt M I, Pankow JS, Bang H, Couper D, Ballantyne CM, Hoogeveen RC, Heiss G
JournalDiabetes
Volume53
Issue9
Pagination2473-8
Date Published2004 Sep
ISSN0012-1797
KeywordsAdiponectin, African Americans, Arteriosclerosis, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Humans, Incidence, Intercellular Signaling Peptides and Proteins, Male, Middle Aged, Proteins, Risk Factors, United States
Abstract

Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the approximately 9-year experience of the 10,275 middle-aged, U.S. African-American and white participants of the Atherosclerosis Risk in Communities (ARIC) study. Adiponectin was measured on stored plasma of 581 incident diabetes case subjects and 572 noncase subjects. Overall hazard ratios (95% CIs) for developing diabetes, for those in the second, third, and fourth (versus the first) quartile of adiponectin were 0.57 (0.41-0.78), 0.39 (0.27-0.56), and 0.18 (0.11-0.27), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, and hypertension and 0.72 (0.48-1.09), 0.67 (0.43-1.04), and 0.58 (0.34-0.99), respectively, after additional adjustment for BMI, waist-to-hip ratio, fasting glucose, insulin, and a score composed of six inflammation markers. The association was of similar magnitude in men and women and in whites and African Americans, but was absent in smokers and in those with a greater inflammation score (interaction P

DOI10.2337/diabetes.53.9.2473
Alternate JournalDiabetes
PubMed ID15331562
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
R01-DK56918 / DK / NIDDK NIH HHS / United States