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Retinal microvascular abnormalities and renal dysfunction: the atherosclerosis risk in communities study.

TitleRetinal microvascular abnormalities and renal dysfunction: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2004
AuthorsWong T Y, Coresh J, Klein R, Muntner P, Couper DJ, A Sharrett R, Klein BEK, Heiss G, Hubbard LD, Duncan BB
JournalJ Am Soc Nephrol
Date Published2004 Sep
KeywordsArteriosclerosis, Female, Humans, Kidney Diseases, Male, Middle Aged, Retinal Diseases, Retinal Vessels, Risk Factors, United States

Microvascular disease has been linked with renal dysfunction in patients with diabetes. The aim of this study was to examine the association of retinal microvascular abnormalities to renal dysfunction among participants of the Atherosclerosis Risk in Communities Study, a population-based investigation in four U.S. communities. At the third examination (1993 to 1995), retinal photography was performed and the presence of retinal microvascular abnormalities was documented using a standard grading protocol. Renal dysfunction was defined as an increase in serum creatinine of at least 0.4 mg/dl or a death or hospitalization as a result of chronic kidney disease between the second (1990 to 1992) and fourth (1996 to 1998) examinations. Among 10,056 people who were included in the study, 270 (2.7%) developed renal dysfunction. After controlling for age, gender, race, diabetes, BP, and other risk factors, individuals with retinopathy (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.4 to 2.8), microaneurysms (OR, 2.0; 95% CI, 1.3 to 3.1), retinal hemorrhages (OR, 2.6; 95% CI, 1.6 to 4.0), soft exudates (OR, 2.7; 95% CI, 1.6 to 4.8), and arteriovenous nicking (OR, 1.4; 95% CI, 1.0 to 1.9) were more likely to develop renal dysfunction than individuals without these abnormalities. Retinal microvascular abnormalities are associated with renal dysfunction, suggesting that common systemic microvascular processes may underlie the development of microvascular damage in the eye and kidneys.

Alternate JournalJ Am Soc Nephrol
PubMed ID15339997
Grant ListEY013939 / EY / NEI NIH HHS / United States