Pulse lineResearch With Heart Logo

Endogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities study.

TitleEndogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2005
AuthorsMudali S, Dobs AS, Ding J, Cauley JA, Szklo M, Golden S H
Corporate AuthorsAtherosclerosis Risk in Communities Study
JournalJ Clin Endocrinol Metab
Volume90
Issue2
Pagination1202-9
Date Published2005 Feb
ISSN0021-972X
KeywordsAndrogens, Androstenedione, Arteriosclerosis, Carotid Stenosis, Cholesterol, Dehydroepiandrosterone Sulfate, Estrone, Female, Humans, Life Style, Lipids, Postmenopause, Reference Values, Risk Factors, Sex Hormone-Binding Globulin, Testosterone, Triglycerides
Abstract

Previous studies have revealed that exogenous estrogen has a beneficial effect on the lipid profile; however, studies examining the relation between endogenous hormones and lipid profiles in postmenopausal women have yielded conflicting results. We sought to characterize the cross-sectional relationship between endogenous hormones and lipid parameters in postmenopausal women with significant (cases, n = 156) and minimal (controls, n = 172) carotid atherosclerosis not taking hormone therapy in the Atherosclerosis Risk in Communities Study. Endogenous hormone status was assessed by measuring levels of estrone, total testosterone, androstenedione, dehydroepiandrosterone sulfate, and SHBG. Free testosterone was estimated using the free androgen index (total testosterone/SHBG). Lipid parameters assessed included total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol. We found that SHBG was significantly associated with a more favorable lipid profile, including lower total and LDL cholesterol and triglycerides and higher HDL cholesterol among controls. This association was less prominent among cases where SHBG was only associated with higher triglycerides and lower HDL cholesterol. The free androgen index was associated with a more atherogenic lipid profile, including increased LDL cholesterol among controls and increased total and LDL cholesterol and triglycerides among cases. These relations were independent of demographic and metabolic factors and health behaviors. In contrast to controls, estrone was associated with higher total cholesterol and triglycerides among cases in multivariate analyses. Our data suggest that endogenous sex hormones may play a role in regulating lipid metabolism in postmenopausal women.

DOI10.1210/jc.2004-0744
Alternate JournalJ Clin Endocrinol Metab
PubMed ID15546905
Grant ListN01 HC55015 / HC / NHLBI NIH HHS / United States
N01 HC55016 / HC / NHLBI NIH HHS / United States
N01 HC55018 / HC / NHLBI NIH HHS / United States
N01 HC55019 / HC / NHLBI NIH HHS / United States
N01 HC55020 / HC / NHLBI NIH HHS / United States
N01 HC55021 / HC / NHLBI NIH HHS / United States
N01 HC55022 / HC / NHLBI NIH HHS / United States